Journal of Addiction Research & Therapy
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vidence from clinical, animal, and neuroimaging experiments suggest that the addictive behavior is associated with
dysregulated dopamine neurotransmission. Precise role of dopamine in establishment and maintenance of addiction however
is unclear. In this context animal studies on the brain reward system and associative memory processing provide a novel insight. It
was shown that both processing involve dopamine neurotransmission and are disrupted in addiction. These findings indicate that
dysregulated dopamine neurotransmission alters the brain processing of not only the reward system but also that of the memory
of association between an addictive substance and reward. These alterations lead to maladaptive motivational behavior leading to
addiction. This concept however is based mostly on the data obtained in laboratory animals because of the paucity of human data.
Due to lack of a reliable technique to study neurotransmission in the live human brain, it has been a problem to study the role of
dopamine in human volunteers. A recently developed dynamic molecular imaging technique however, provides an opportunity
to study these concepts in human volunteers because the technique allows detection, mapping and measurement of dopamine
released in the live human brain during task performance.
Rajendra Badgaiyan completed his M.D. and M.A. (Psychology) in India and finished postdoctoral training at University of Oregon, University of
Pittsburgh and Harvard University. He completed residency training in Psychiatry at Harvard and currently directs the outpatient addiction clinic and
Neuroimaging Laboratoryat SUNY Buffalo. He is a member of the editorial boards of 12 journals and Chief/executive editor of 3 journals. Badgaiyan
received several awards for research and he is recognized as the original developer of single scan dynamic molecular imaging technique that allows
detection, mapping and measurement of dopamine released during task performance in the live human brain
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