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ISSN: 2168-9652

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Gregory Lee

Gregory Lee Gregory Lee
UBC Center for Reproductive Health
University of British Columbia
Vancouver, Canada
Biography

Upon completion of his Ph D degree in Biophysical Chemistry at California Institute of Technology in 1972, he joined UCSD as a NIH Postdoctoral Fellow to carry out pioneer work on general ligand affinity chromatography. In 1976, he studied enzymology and biochemical genetic at the National Institute of Health and in 1981, he was appointed as a faculty member and director of the Andrology Laboratory at the University of British Columbia. During the last two decades, he has created numerous monoclonal antibodies for diagnostic and therapeutic applications in human health care, including RP215 and GHR106 for potential use as anti-cancer drugs.

Research Interest

Research and Development of Antibody-Based Anti-Cancer Drugs

- RP215 monoclonal antibody was shown to recognize specifically a carbohydrate-associated epitope located on the variable regions of cancer cell expressed immunoglobulins, designated in general as CA215.

- Structural elucidation of carbohydrate-associated epitope in CA215 which is recognized by RP215 monoclonal antibody (Mab)

- Humanizations of RP215 Mab for preclinical studies

- Generations of Rat anti-idiotype Mabs as candidates for the development of anti-cancer vaccines in humans

- Establishment of an Anti-GnRH receptor Mab, GHR106, as a substitute of short-acting GnRH analogs for antibody-based anti-cancer drugs, as well as preclinical studies.

- Elucidation of mechanisms of action for RP215 and GHR106 as antibody-based anti-cancer drugs.

- Elucidation of a carbohydrate-associated epitope recognized by RP215 monoclonal antibody.

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Publications

Dual Differential Roles of Cancerous Immunoglobulins as Suggested by Interactions with Human Serum Proteins
Gregory Lee
Review Article: J Clin Cell Immunol 2015, 6: 385
DOI: 10.4172/2155-9899.1000385
 
Cancerous Immunoglobulins in Cancer Immunology
Gregory Lee
Review Article: J Clin Cell Immunol 2014, 5: 279
DOI: 10.4172/2155-9899.1000279
 
Potential Roles of Cancerous Immunoglobulins in the Immunology of Cancer Cells
Gregory Lee, Cheng-Yuan Huang, Yiting Tang and Hao Zhang
Research Article: J Clin Cell Immunol 2014, 5: 200
DOI: 10.4172/2155-9899.1000200
 
Two Distinct Humanized Monoclonal Antibodies for Immunotherapy of Ovarian Cancer
Gregory Lee, Cheng-yuan Huang and Bixia Ge
Review Article: J Cancer Sci Ther/Vol.6.3 110-116 (2014)
DOI: 10.4172/1948-5956.1000258
 
The Relationships between Toll-like Receptors and RP215-associated Immunoglobulins Expressed by Cancer Cells
Gregory Lee, Cheng-Yuan Huang, Hao Zhang and Yiting Tang
Review Article: J Cancer Sci Ther/Vol.6.3 077-080(2014)
DOI: 10.4172/1948-5956.1000252
 
Similar Gene Regulation Patterns for Growth Inhibition of Cancer Cells by RP215 or Anti-Antigen Receptors
Yiting Tang, Hao Zhang and Gregory Lee
Research Article: J Cancer Sci Ther/Vol.5.5 200-208 (2013)
DOI: 10.4172/1948-5956.1000207
 
Monoclonal Anti-idiotype Antibodies against Carbohydrate-associate Epitope for Anti-Cancer Vaccine Development
Gregory Lee, Anthony P. Cheung, Bixia Ge, Mingang Zhu, Peter P. Li, Eric Hsu and Teng-Kai Huang
Research Article: J Vaccines Vaccin 2010, 1:106
DOI: 10.4172/2157-7560.1000106
 
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