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Hiroyuki Hirai
Department of Genetics
Stem Cell Institute
University of Minnesota
USA
Biography
Mr. Hirai, Research Associate of Genetics, Cell Biology and Development at the University of Minnesota, is an investigator of the Stem Cell Institute and the Minnesota Supercomputing Institute. He received his Ph.D. in Biochemistry from Tokyo Medical and Dental University. He studied muscle stem cell biology and therapy at Stem Cell Institute, University of Minnesota as a postdoctoral fellow. He then studied biochemical analysis of nuclear remodeling in somatic cell nuclear cloning. Recently he fused the transactivation domain (TAD) of MyoD to the pluripotency gene Oct3/4 and radically improved the efficiency of making iPSCs. In addition, fusion of the MyoD TAD to the cardiac transcription factor Mef2c facilitates the direct reprogramming of non-cardiac fibroblasts to cardiomyocyte-like cells.
Research Interest
Dr. Hirai's current research interests are to develop a transdifferentiation strategy and stem cell biology. These studies are expected to contribute to the development of celluar/gene therapy and regenerative medicine. He has been investigating progenitor cells, somatic stem cells and induced pluripotent stem cells (iPSCs) of mouse and human. He continues the research of other regulators necessary for the direct reprogramming and iPSCs reprogramming.
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