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Spectroscopic Studies of the Bis-3,6-Alkylamidoacridines as Potential Topoisomerase I Inhibitors
In this paper, the interaction of bis-3,6-alkylamidoacridines with calf thymus DNA (ctDNA) and their inhibitory effect on topoisomerase I are investigated. The binding mode of the low-molecular ligands to ctDNA was determined using UVvis absorption spectrophotometry, fluorescence spectrophotometry and circular dichroism. The binding constants for t... Read More»
Danica Sabolová, Júlia Kudlácová, Ladislav Janovec and Ján Imrich
Research Article: Biochem Physiol 2013, 2:112
DOI: 10.4172/2168-9652.1000112
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