Ladislav Janovec | OMICS International
ISSN: 2168-9652

Biochemistry & Physiology: Open Access
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Ladislav Janovec

Slovak Republic

Spectroscopic Studies of the Bis-3,6-Alkylamidoacridines as Potential Topoisomerase I Inhibitors

In this paper, the interaction of bis-3,6-alkylamidoacridines with calf thymus DNA (ctDNA) and their inhibitory effect on topoisomerase I are investigated. The binding mode of the low-molecular ligands to ctDNA was determined using UVvis absorption spectrophotometry, fluorescence spectrophotometry and circular dichroism. The binding constants for t... Read More»

Danica Sabolová, Júlia Kudlácová, Ladislav Janovec and Ján Imrich

Research Article: Biochem Physiol 2013, 2:112

DOI: 10.4172/2168-9652.1000112

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF