Journal of Obesity & Weight Loss Therapy
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Alpha amylases are enzymes which hydrolyze dietary starch into disaccharides and tri-saccharides which are further
converted by other enzymes to glucose to supply the body with energy. Thus, alpha amylase acts as a key player in metabolic
energy homeostasis. Hence, assessment of the activity of alpha amylase in metabolic disorders such as in obesity and diabetes is
of interest. Therefore, the aim of the present study was to demonstrate the role of alpha amylase in the pathological progression
of obesity and diabetes and to elucidate the effect of trace mineral in controlling its activity. To implement the hypothesis,
alpha amylase activity along with various biochemical markers such as glucose level, triglyceride, total cholesterol, C-reactive
protein and creatinine level were assessed. In addition, an attempt was done to characterize the in vitro modulation of alpha
amylase activity by trace mineral (zinc). In obesity and diabetes, sufficient deviation was observed in the level of biochemical
markers including blood glucose, lipid profile, C-reactive protein (CRP), creatinine and alpha amylase activity when compared
with healthy participants. Alpha amylase activity found to be positively linked with Body Mass Index (BMI). In addition, alpha
amylase also showed a positive correlation with blood glucose level and duration of diabetes. Thus, it can be stated that alpha
amylase can initiate a cross-link mechanism between BMI and blood glucose level facilitating the propensity of obesity and
diabetes. Furthermore, alpha amylase also showed a significant positive correlation with CRP, an ideal inflammatory marker,
suggesting an intricate role of alpha amylase on propagation of inflammation in obesity and diabetes. Serum creatinine also
showed an insignificant positive link with alpha amylase activity in obesity and type-2 diabetes. Moreover, in vitro serum
fortification with zinc represents a significant inhibition on the activity of alpha amylase in obesity and diabetes. Thus, alpha
amylase can be considered as a major risk factor in the pathogenesis of obesity and diabetes associated complications and
supplementation of zinc trace mineral can be suggested to control this impetuous marker.
Mohammad Salim Hossain has completed his graduation in Pharmacy from University of Dhaka, obtained his PhD form Tottori University, Japan. Currently he is a Professor of Pharmacy at Noakhali Science and Technology University, Bangladesh. He has vast experiences in studying the biochemical and molecular regulation of adipogenesis and adipocyte inflammation. He aims to explore the cross linking parameters between obesity and other related life style diseases. He is also studying natural products for combating obesity and linked non-communicable diseases.