Journal of Obesity & Weight Loss Therapy
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Linn has been used in diarrhoea, dysentery, digestive disturbances and diabetes and vitiated conditions of
tridoshas, and improves digestion. The stimulation of PTP-1B also modulates the insulin, leptin and integrin signaling, and
thereby results increased fatty acid synthase (FAS) activity and obesity. The present study was designed to investigate the anti-
obesity effect of
Linn on high fat diet-induced obesity. Male Wistar albino rats weighing 170-230 g were employed
in present study. Experimental obesity was induced by treatment with high fat diet for 10 weeks.
extract 100, 200 and
400 mg/kg and gemfibrozil 50 mg/kg as standard drug were administered orally from 7
weeks. HFD treatment for 10
weeks caused significant (p<0.05) increase in % body weight, BMI, LEE index, different fat pad and liver weights, serum glucose,
triglyceride, LDL, VLDL, cholesterol, free fatty acid, ALT, AST; and tissue TBARS, nitrate/nitrite, and significant decrease in food
intake (g and kcal), serum HDL and tissue glutathione were observed in HFD control rats. Treatment with
gemfibrozil significantly attenuated these HFD induced changes, as compared to HFD control. The effect of
200 and 400
mg/kg was more pronounced in comparison to the standard drug. On the basis of the results obtained, it may be concluded that
the methanolic extract of stem bark of
Linn has significant anti-obesity potential against HFD induced obesity,
possibly due to modulation of FAS and PTP-1B signalling in rat.
Rohit Goyal has completed his PhD at the age of 28 years from Punjab Technical University in specialization Pharmacology. He is the Associate
Professor in School of Pharmaceutical Sciences, Shoolini University, Solan, HP, India. He has published around 10 papers in reputed journals
and serving as an editorial board member of reputed journals. The basic research areas are preclinical pharmacological screenings, molecular
pharmacology, toxicology and metabolic syndrome etc.
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