Assessment Of Circulating Adipokine Levels In Type 2 Diabetes Mellitus In Lagos, Nigeria | 6394
Journal of Obesity & Weight Loss Therapy
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Type 2 diabetes remains a global concern with its numerical increase occurring in developing countries which
include Nigeria and adipose tissue-secreted factors called ?adipokines? are involved in energy homeostasis and regulation of
glucose and lipid metabolism. Hence, this study was undertaken with the aim of investigating adipokine levels in the Type 2
This is a cross sectional study conducted in Lagos University Teaching Hospital (LUTH), a700 bed tertiary centre
in the city of Lagos, Southwest Nigeria. 53 diabetic subjects with mean? standard deviation (56.72?10.44) and 27 non-diabetic
controls (38.67?9.63) were recruited into the study. Fasting blood Glucose (FBG), glycosylated haemoglobin (HbA₁C), leptin,
and resistin were assayed. Body mass index (BMI) was also measured.
Mean BMI was higher but not statistically significant in diabetics than in non diabetics (diabetics 28.77?5.35; non
diabetics 27.38?6.04; p > 0.05). This corroborates other studies that the higher level of adiposity predisposes higher level of FBG
and HbA1C and to the incidence of DM as a result of the effect of increasing fat mass on insulin sensitivity [1,2].Resistin was
significantly higher in diabetics (diabetics 31.26?2.5; non diabetics 16.61?2.16; P < 0.01) compared to non-diabetics. Leptin
correlated very strongly with BMI (r = 0.620, p< 0.0001) and was significantly higher in females than males (female: 9.72?1.70;
male: 1.79?0.54; p < 0.0001) which agrees with the study conducted by Zimmet and Thomas .
This study concludes that circulating adipokines have variable effect on the glucose and fat metabolism. BMI and
resistinlevels were higher in diabetics. Leptin was found in this study to correlate very strongly with BMI (adiposity). There was
also a strong gender dependence observed as leptinlevel was signficantly higher in females than males.
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