Association Between Obesity And Biliary Dysmotility In Healthy Individuals In Ukraine | 6367
Journal of Obesity & Weight Loss Therapy
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Lifestyle modification leads to obesity rates growth not only in developed, but in developing
countries, however causes are different. Poor diet (flour-based, low quality food, high prices for high-quality food, low fruits/
vegetables consumption (less than 600g/day, 46.4% lower than Europe)) and insufficient physical activity result in obesity rates
increase in Ukraine (for 2004-2006 ? by 31.9%). Along with obesity rates increasing, cholecystectomy in Ukraine got 2nd place
among all surgical interventions. Gallstone formation is strongly connected with biliary dysmotility, which could be associated
To characterize biliary motility in healthy subjects depending on their weight status.
Healthy individuals (N=53: 16 men, 37 women) participated in the study. Body mass index (BMI, kg/m
calculated, and three groups were formed according to BMI ? normal weight/control (BMI<24.99 kg/m
), overweight (OW;
) and obese (OB; BMI_30.00 kg/m
). The fasting gallbladder volume (GV, ml) and its MgSO4-stimulated
contractility (20?, 40? and 60? after per oral 50.0 ml of 25% solution) (K20%, K40%, K60%, %) was measured using abdominal
ultrasonography. There were used the signs to describe biliary motility features for each particular period: ?+? ? gallbladder
contractility; ??? - its relaxation.
All control group subjects had similar biliary motility: ?++??. Forty percent of OW had ?++??, 40.0% - ?+?+?, 20.0%
- ?+++?. Among OB 57.1% had ?++??, 14.3% - ?+?+?, ?+++?, and ?+? ??. The fasting GV was significant larger among OB
(75.8?12.7 ml) compared to control (39.5?8.2 ml, p=0.040) and OW (38.5?4.1 ml, p=0.002). OB has significant lower K20%
than OW (52.9?2.0% and 61.4?5.6%, p=0.003). It was no difference in K40% and K60% between groups. A significantly positive
correlation was found between BMI and GV (r=0.753, p=0.002) for OB.
Obese subjects showed larger GV, decreased contractility and discoordinated biliary motility.
It could be physiologically inadequate and may lead to biliary sludge/gallstone formation. These findings require more research.
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