Association Of Vitamin D Receptor (VDR) Gene Polymorphism And Vitamin D Status In Knee Osteoarthritis | 6519
Journal of Obesity & Weight Loss Therapy
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Evidence suggests that low serum levels of vitamin D may increase the severity of Osteoarthritis (OA). VDR gene
polymorphism is known for its association with osteoporosis. The inverse relationship between osteoporosis and OA suggests
that VDR gene polymorphism is a candidate gene to be associated with OA. This study was done to analyze the association of
vitamin D receptor gene polymorphism (Taq1 and Apa I) and serum vitamin D levels in knee osteoarthritis
This case control study consisted of 180 Osteoarthritis Knee patients and 150 controls. Cases were clinically diagnosed
according to ACR criteria. Gradation of the disease was done by using KL grading system on the basis of radiological findings.
The serum levels of vitamin D were assessed by using kit of Enzyme Linked Immunosorbent Assay. Detection of VDR gene
polymorphisms (Taq1 and Apa I) were done by PCR-RFLP technique
We observed an insignificant association for genotypes of TaqI(p=0.086) and ApaI(p=0.60) polymorphism between
cases and controls.However, for TaqI marginal significant association (p=0.053, OR 1.4, 95% CI 1.008-1.945) was observed
between wild type(T) allele and mutant type(t) allele, but for Apa I, there was no significant difference (p=0.334, OR 1.17, CI
1.367-1.867) between wild type(A) allele and mutant type(a) allele.We observed a significant association of low level of serum
vitamin D levels in homozygous mutant(tt) genotypes as compared to heterozygous(Tt) and wild type(TT) genotypes. But In case
of ApaI, we found higher serum vitamin D levels in homozygous mutant(aa) genotype in comparison to heterozygous(Aa) and
wild type(AA) genotype but this difference was not statistically significant
Though insignificant association was found between osteoarthritis and the genotypes of TaqI and ApaI
polymorphism, a significant association with mutant allele of TaqI(t) was observed. Additionally, the association of mutant allele
with reduced level of vitamin D was noted.
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