Changes In Anthropometric Parameters And Concentrations Of Leptin And Adiponectin In Extreme Obese Patients After Implantation Of A Gastric Balloon | 36285
Journal of Obesity & Weight Loss Therapy
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Fatty tissue derived adipocytokines regulate appetite, but also impair systemic metabolic homeostasis and make the patients
prone to inflammatory related disorders. We examined whether weight loss in patients after implementation of a gastric
balloon is reflected in the concentration of leptin and adiponectin in blood. The study group included 18 obese patients (BMI
>39.9, mean age 39.5±12.1 years, 12 men, 6 women), undergoing implementation of a gastric balloon. The control group
consisted of 18 healthy volunteers. The adiponectin and leptin concentrations in the sera as well as the calculated % body
fat and indicators: BMI, WHR, VAI, BAI, WHtR were determined prior to implementation and after the balloon removal.
Afterwards, further parameters were calculated: % excessive weight loss, % weight loss. All the parameters in the tested group
as well as leptin concentration were noticeably upregulated and adiponectin concentration was significantly lower compared
to controls. After the treatment we observed the amelioration of the anthropometric parameters with no significant changes in
the adiponectin level. The leptin concentration both in the whole group and in men’s group correlated positively with chosen
parameters reduction. Lack of the adiponectin upregulation appropriate to the anthropometric changes after the treatment
suggests no long-lasting benefit to the obese patients’ metabolism.
Edyta Blus graduated MA at the age of 25 years from University of Lodz. From 2008 to 2011 she worked as a research assistant at the Institute of Medical Biology Polish Academy of Sciences. Since 2011, she works as an assistant science teaching in the Department of Pathophysiology and Clinical Immunology, Medical University of Lodz. She is co-author of several scientific publications and in 2012 she opened a PhD.