Control Of Skeletal Muscle Mass During Calorie Restricted Weight Loss In Obese Women: Protein Synthesis Vs Degradation | 6452
Journal of Obesity & Weight Loss Therapy
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Skeletal muscle (SM) not only plays an important role in locomotion, it is now recognized as an integral part of whole-body
metabolism and overall health. However, during weight loss, the main treatment strategy for obesity, loss of fat free (lean
muscle) mass is frequently reported. Maintenance of skeletal muscle mass is dependent upon nutrient stimulation of protein
synthesis via the mTOR signaling pathway, however, during caloric restriction a decrease (atrophy) in SM may be driven by
a homeostatic shift favoring protein degradation. Therefore elucidating the mechanisms that control protein synthesis and
degradation during weight loss is required. Increased dietary protein in a calorie restricted (CR) diet may provide additional
benefit by preserving fat free mass compared to a standard-protein, high-carbohydrate diet. Our study has investigated the
potential effect of weight loss diets on gene expression in skeletal muscle, particularly focusing on biosynthesis, degradation and
how increased dietary protein may influence the expression of genes in the ubiquitin proteosome (UPP) and mTOR signaling
pathways to minimize muscle loss. The identification of the physiological and biological molecular mechanisms underlying the
metabolic disturbances observed in obesity and how weight loss affects these mechanisms will be a key step in developing better
weight management regimes to combat the obesity epidemic.
Cassandra McIver completed her Ph.D in 2006 from The Queen Elizabeth Hospital and The University of Adelaide, Australia examining molecular
markers in colorectal cancer using microarrays. Dr. McIver is currently a postdoctoral research fellow at The University of Adelaide and The Basil
Hetzel Institute for Translational Research (BHI).
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals