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Dietary Modification With High Salt Attenuates Obesity And Hyperlipidemia In High Fat Induced Obese Mice | 106156
ISSN: 2165-7904
Journal of Obesity & Weight Loss Therapy
Open Access
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The prevalence of obesity
is an alarming condition
for mortality and morbidity
leading to other lifestylerelated
diseases worldwide.
Finding out the new way
to combat obesity is the
most warrant. The aim of
the present study was to
investigate the effect of a
modified diet with high-salt
(4% NaCl) on fat deposition in
high-fat diet induced obese
mice. Forty healthy Swiss
Albino mice (Sex: Female) were
taken and divided equally into
two groups named as a nonobese
group and obese group.
In the case of a non-obese
group, mice were fed a normal
diet, normal diet along with
high-salt, high-fat diet, and
high-fat diet along with highsalt
for 6 weeks. On another
hand, to induce obesity, mice
were fed high-fat for 2weeks
and then treated with highfat
diet along with high-salt,
normal diet, normal diet along
with high-salt again for 6weeks.
The effects of these treatments
on body weight, feed intake,
Lee index, organs weight and
levels of serum triglycerides
(TGs), total cholesterol (TC),
high density lipoproteincholesterol
(HDL-C), low
density lipoprotein-cholesterol
(LDL-C), SGOT and SGPT,
and atherogenic index of
plasma (AIP) were analysed.
In case of non-obese group,
treatment with high-fat diet
along with high-salt showed
a significant decrease in body
weight (p<0.05), organs weight
(liver, heart, and abdominal
fat) (p<0.05), serum TG, TC,
LDL-C (p<0.05) levels, AIP
(p<0.05) value and SGOT and
SGPT levels (p???0.05) whereas
significant elevation was
noticed in HDL-C (p<0.05)
level compared to the HFD
group. Furthermore, in case
of obese group treatment
with high-fat diet along with
high-salt and normal diet
along with high-salt showed
a significant declination in
body weight (p<0.05), Lee
index (p<0.05), organs weight
(liver, heart, and abdominal
fat) (p<0.05), serum TG, TC,
LDL-C (p<0.01) levels, AIP
(p<0.01), SGOT and SGPT levels
(p<0.05) whereas significant
elevation was noticed in HDL-C
(p<0.01) level compared to
the Obese control group.
From the observations of the
study performed, it could be
predicted that high salt (4%
NaCl) diet has an inhibitory
action on fat absorption which
may be effective to attenuate
the obesity and obesity-related
parameters.
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