alexa
Reach Us 443308186230

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Direct Action Of Obesity-inducing Antipsychotics On Human Adipocytes | 6381
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1582

Journal of Obesity & Weight Loss Therapy received 1582 citations as per Google Scholar report

Journal of Obesity & Weight Loss Therapy peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • Centre for Agriculture and Biosciences International (CABI)
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • CABI full text
  • Cab direct
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • University of Bristol
  • pubmed
Share This Page

Direct action of obesity-inducing antipsychotics on human adipocytes

International Conference and Exhibition on Obesity & Weight Management

Nira Ben-Jonathan

ScientificTracks Abstracts: J Obes Wt Loss Ther

DOI: 10.4172/2165-7904.S1.002

Abstract
A typical antipsychotics (AAP) are prescribed to millions of patients worldwide with schizophrenia, bipolar disorder, major depression, and autism. In spite of their ability to ameliorate many mental problems, AAP have serious metabolic side- effects, including substantial weight gain, dyslipidemia, diabetes, and cardiovascular disease. The primary therapeutic target of AAP are dopamine (DAR) and serotonin (5-HTR) receptors. The mechanisms underlying the metabolic side effects of AAP are unknown, but have been attributed to their central action. We discovered expression of functional DAR and 5-HTR subtypes in human adipose tissue. Incubation of adipose explants, primary adipocytes and human adipocyte cell lines with selected AAP suppressed leptin and adiponectin, and increased basal and isoproterenol-stimulated lipolysis. Treatment of female rats with olanzapine caused a 85-90% suppression of leptin and adiponectin, and a 4-fold increase in interleukin-6 (IL-6) expression in fat tissue within 24 hrs, concomitant with increased food intake and weight gain in 2-3 days. We conclude that direct activation of DAR and 5-HTR subtypes in adipose tissue underscores peripheral actions of AAP which complement, or override, their central actions, leading to weight gain and the metabolic syndrome. Given the millions of patients who are chronically treated with AAP, most pharmaceutical companies are developing new drugs in this class. Human adipocytes could be integrated into the screening paradigms of candidate drugs for the identification of undesirable metabolic activities prior to costly animal studies and clinical trials. This investigation also identified a potential novel target for the treatment of obesity.
Biography
Nira Ben-Jonathan has published 165 manuscripts, edited one book, and contributed 12 chapters to textbooks and encyclopedias. Early in her career she studied the neuroendocrine regulation of pituitary functions while the current focus of her research is on breast cancer, adipose tissue and human obesity. She was awarded the NIH Research Career Development Award, was elected Fellow of the AAAS, elected Chairman of the Gordon Research Conference, and received the Rieveschl Award for Outstanding Scientific Research. She has been a member on numerous committees, serving as chairman on five NIH study sections.
Top