Endocannabinoid Control Of Gut-brain Hunger Signaling | 36258
Journal of Obesity & Weight Loss Therapy
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Endocannabinoids are lipid-derived signaling molecules that control food intake and energy metabolism. Recent evidence
from our laboratory suggests that tasting dietary fats triggers endocannabinoid signaling within the rat upper small intestine,
and this signaling event promotes the intake and possibly preference for fat-rich foods. We now report a broader role for the gut
endocannabinoid system in the control of hunger and eating, and identify critical molecular and neural pathways that regulate
these physiological processes. Food deprivation induces biosynthesis of the orexigenic endocannabinoid, 2-arachidonoyl-snglycerol
(2-AG), in the jejunum mucosa of rats in a time-dependent manner through a mechanism that includes increases in local
levels of the 2-AG precursor, 1-stearoyl,2-arachidonoyl-sn-glycerol (SAG). Treatment with tetrahydrolipstatin-an inhibitor of
diacylglycerol lipase (DGL), which is a critical enzyme that hydrolyzes SAG and generates 2-AG-inhibits production of jejunal
2-AG, suggesting a role for DGL in the formation of 2-AG in the intestine. Furthermore, deprivation-induced biosynthesis
of 2-AG in the jejunum is blocked by complete subdiaphragmaticvagotomy or peripheral treatment with the muscarinic
acetylcholine receptor antagonist, atropine. Peripheral administration of atropine, or the peripherally-restricted cannabinoid
CB1R antagonist, AM6546, inhibits re-feeding after a 24-hr fast. Collectively, the results suggest that food deprivation drives
the biosynthesis of 2-AG in the jejunum through a vagal mechanism that includes activation of local muscarinic acetylcholine
receptors. Moreover, this gut-brain signaling pathway might participate more broadly in the integrative and dynamic control
of feeding and energy balance.
Nicholas V Di Patrizio’s passion for scientific discovery was solidified during his undergraduate studies at Temple University in Philadelphia. He subsequently earned a Biomedical PhD in the Neurosciences at Drexel University College of Medicine, and did his Postdoctoral research at the University of California, Irvine School of Medicine. He is a recipient of the prestigious National Institutes of Health Pathway to Independence K99/R00 grant award from the National Institute on Drug Abuse. He recently launched his independent research program as an Assistant Professor of Biomedical Sciences at the University of California, Riverside School of Medicine.