alexa
Reach Us 443308186230

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
ER-DOMA - The Entangled Relationship Between Diabetes, Obesity, Metabolic Syndrome And Aging | 14781
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 1582

Journal of Obesity & Weight Loss Therapy received 1582 citations as per Google Scholar report

Journal of Obesity & Weight Loss Therapy peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • Centre for Agriculture and Biosciences International (CABI)
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • CABI full text
  • Cab direct
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • University of Bristol
  • pubmed
Share This Page

ER-DOMA - The entangled relationship between diabetes, obesity, metabolic syndrome and aging

2nd International Conference and Exhibition on Obesity & Weight Management

Vinod Nikhra

ScientificTracks Abstracts: J Obes Weight Loss Ther

DOI: 10.4172/2165-7904.S1.010

Abstract
Diabetes, obesity and metabolic syndrome are the essence of metabolic disorders. A whole gamut of research data indicate that they are complexly entangled and bear a close inter-relationship. These disorders are life-style diseases as well, having genesis in modifiable modern dietary habits and technology-driven sedentary living patterns, apart from non-modifiable genetic makeup. They have an important impact on the morbidity and mortality patterns directly and through their effects on individual aging process. The aging population has a higher incidence of diabetes. On the other hand, overweight and obese persons have higher incidence of diabetes. The research has proven that obesity accelerates aging of adipose tissue, which in turn leads to activation of cascade of various metabolic pathways responsible for aging. Diabetes, too, appears to accelerate aging at cellular level through metabolic alterations. The experiments in normal mice, variously knocked-out-mice and agouti mice have unfolded the understanding of genetic basis and metabolic pathways. In experiments, the agouti mice, which are genetically obese, having high levels of reactive oxygen species (ROS), increased DNA damage and higher expression of inflammatory markers, lacking telomerase develop shorter telomeres during successive generations. These changes are comparable to normal aging mice. Thus, inference from the research indicates that obesity increases the formation of ROS in adipose cells, and shortens telomeres, which in turn, activates the p53 tumor suppressor leading to inflammation manifested by infiltration by macrophages and elevated level of cytokines. This has been shown to lead to insulin resistance, impaired glucose tolerance and diabetes. Similarly, the histological and physiological changes in aging organs are associated with oxidative stress, genetic instability and disruption of homeostatic pathways. Aging has been linked to telomere shortening due to impaired cellular ability to detoxify ROS, leading to p53 activation. This potentially impairs insulin secretion and sensitivity. There are, thus, similarities in metabolic dysfunction and deregulation in obese states, diabetes and aging. It has been highlighted that diabetes, obesity and aging may share similar mechanisms and metabolic pathways at cellular level. Whether diabetes-mediated or obesity-mediated aging is reversible? The caloric restriction with adequate nutrition (CRAN) reduces aging in normal population and has a favorable impact on glucose homeostasis. The CRAN, a selective CRAN or a modality having favorable impact on homeostasis, can be an answer for the exacerbated aging in the special conditions like diabetes, obesity and metabolic syndrome.
Biography
Vinod Nikhra, M.D., is Fellow of International Medical Sciences Academy and Fellow of Royal Society of Medicine. He is trained in Internal Medicine, Endocrinology and Clinical Nephrology. He has authored 4 books, which include The Anti-Obesity Guide and Aging slowly, Living longer , and contributed more than 46 papers in reputed journals and has been an editor for Journal of Association for Health in Middle Aged and a reviewer for International Journal of Obesity (the Nature group) and Family Practice (the Oxford group). He is a senior consultant physician and on teaching faculty at Hindu Rao Hospital, Delhi, India.
Top