alexa Gastric Leptin- An Exocrine Secretion Regulating Food Intake | 14862
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference and Exhibition on Obesity & Weight Management

Moise Bendayan and Philippe Cammisotto
Accepted Abstracts: J Obes Weight Loss Ther
DOI: 10.4172/2165-7904.S1.012
Abstract
Leptin plays important roles on the nutritional and energy status of the organism. It is secreted in an endocrine way by the adipose tissue and in an exocrine way by the gastric mucosa. Gastric epithelial chief cells express and secrete leptin into the gastric lumen through their RER-Golgi-secretory granules regulated pathway together with classical gastric enzymes such as lipase and pepsinogen. Upon food intake, the content of the granules is released into the gastric lumen. Leptin resists the drastic proteolytic conditions of the gastric juice thanks to its binding to the soluble isoform of the leptin receptor. The formation of the leptin-leptin receptor complex takes place in the secretory granule prior release. Once secreted, this complex crosses the pyloric sphincter reaching the duodenal lumen. Transmembrane leptin receptors lining the intestinal cells apical microvilli bind the luminal leptin and internalize it through clathrin-coated vesicles. Leptin regulates absorption of nutrients and participates in the intestinal mucosa integrity. However some of the internalized leptin is transported through transcytosis to the baso-lateral membrane to be released into the interstitial space to reach the blood circulation and the hypothalamic target cells. Since leptin is normally present in the gastric lumen and reaches the circulation through transcytosis across the intestinal cells, we designed an oral formulation of leptin that by using the same pathway can reach the blood circulation. Such an oral formulation of leptin is able to control food intake by various normal animal models and restores leptin levels in animal models expressing leptin deficiency.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7