alexa Identification Of MiR-26a As A Target Gene Of Bile Acid Receptor BPBAR-1/TGR5
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

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10th International Conference and Exhibition on Obesity & Weight Management
December 08-10, 2016 Dallas, USA

Xiaosong Chen
The Union Hospital of Fujian Medical University, China
Posters & Accepted Abstracts: J Obes Weight Loss Ther
DOI: 10.4172/2165-7904.C1.043
Abstract
GPBAR1/TGR5 is a G protein–coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity and improving glucose regulation, however, the mechanism of which is still unclear. Here we report that TGR5 is involved in mediating the anti-obesity and antihighperglycemia effect of a natural compound, oleanolic acid. By comparing the miRNA profiles between wild-type and TGR5-/- livers after OA treatment, we identified miR-26a as a novel downstream target gene of TGR5 activation. The expression of miR-26a in the liver was induced in a TGR5-dependent manner after feeding the mice with a bile acid diet. TGR5 activation strongly increased the expression of miR-26a in macrophages, including the Kupffer cells in the liver. We further demonstrated that JNK pathway was required for miR-26a induction by TGR5 activation. Interestingly, we located the TGR5-responsive DNA element to a proximal region of miR-26’s promoter, which was independent of the transcription of its host genes. These results unravel a new mechanism by which bile acid receptor TGR5 activates a miRNA gene expression.
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