Influences Of Palmitoleic Acid In Metabolism And Gene Expression Of White Adipose Tissues Cells | 96864
Journal of Obesity & Weight Loss Therapy
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We have recently demonstrated that palmitoleic acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for
energy production in white adipose cells. In the present study, we tested the hypothesis that palmitoleic acid modulates
bioenergetic activity in white adipocytes. For this, 3 T3-L1 pre-adipocytes were differentiated into mature adipocytes in
the presence (or absence) of palmitic (16:0) or palmitoleic (16:1n7) acid at 100 or 200 ?M. The following parameters were
evaluated: lipolysis, lipogenesis, fatty acid (FA) oxidation, ATP content, oxygen consumption, mitochondrial mass, citrate
synthase activity and protein content of mitochondrial oxidative phosphorylation (OXPHOS) complexes. Treatment with
16:1n7 during 9 days raised basal and isoproterenol-stimulated lipolysis, FA incorporation into triacylglycerol (TAG), FA
oxidation, oxygen consumption, protein expression of subunits representing OXPHOS complex II, III, and V and intracellular
ATP content. These effects were not observed in adipocytes treated with 16:0. Palmitoleic acid, by concerted action on lipolysis,
FA esterification, mitochondrial FA oxidation, oxygen consumption and ATP content, does enhance white adipocyte energy
expenditure and may act as local hormone.
Maysa Mariana Cruz will completed her PhD at the age of 28 years from Federal University of São Paulo. She is a pharmacist, Master of science and has published 1 paper as first author and 7 papers as coauthor.