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In-vitro And In-vivo Anti-obesity Activity Of Wood Of Pterocarpus Marsupium | 6503
Journal of Obesity & Weight Loss Therapy
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Obesity is characterized by accumulation of triacylglycerol in adipocytes. Obesity is a condition in which excess body fat
is accumulated to an extent that health may be negatively affected. The symptoms of obesity have been increased very
widely in the recent time period and still increasing. Pharmacological factor involved in obesity includes lipoprotein lipase
having a central role in metabolism of both triglyceride rich particles and high density lipoprotein.
(Fabaceae) commonly known as Bijasar/Vijaysar/ Indian kino in important plant used traditionally for various medicinal
purposes. Several chemical constitutents like pterosupin, marsupin, pterostilbene, epicatechin, etc. have been isolated. The
plant has various pharmacological activities like antifungal, analgesic, anti-inflammatory, hepatoprotective, etc. The plant has
been found to possess diverse number of biological activities. The
tree has some medicinal property and is thus
commercially exploitable. During the last five decades, apart from the chemistry of the
progress has been achieved regarding the biological activity and medicinal applications of
It is now considered as a
valuable source of unique natural products for development of medicines against various diseases and also for the development of
industrial products.The aim of the study was to compare the lipid lowering activity of
wood, a traditional
Indian plant, with a standard pharmacological agent sibutramine, in the management of obesity. The trial was carried out with
Sprague Drawly rats with 6 animals per group. Obesity was induced to each group except the normal control group for 30
days and treatment was given for 15 days. The change in the lipid profile was carried out to check the lipid lowering effect of
compared to sibutramine the standard most widely recommended for obesity. Preliminary phytochemical screening
yielded the aqueous extract concentration of 8.8% w/w while that of methanolic extract was 21.76% w/w and phenolics isolated
was of 0.21% w/w. Further, the test showed the presence of tannins, flavonoids, alkaloids, phenols and carbohydrates. The total
phenolic content was 37.72? 0.14 mg and 46.02 ? 0.27 mg for aqueous and methanolic extract respectively. The total flavonoid
contents were 232.91 ? 1.37mg and 251.92 ? 1.26 mg for aqueous and methanolic extract respectively.
drug analysis was
carried out to check the efficacy of dose required for lipase inhibitory activity with a standard pH stat technique recommended by
Tietz et. al., (1989) with minor modifications. The data showed IC50 at 150 μg/ml for P. marsupium and 40μg/ml for sibutramine.
While the DPPH free radical scavenging activity for
%inhibiton of 300 μg/ml and 500 μg/ml for aqueous and
methanolic extract respectively.
study for the same were carried out and their relative food intake and body weight were
measured during the course of study and prevailed that both were increasing when the obesity was induced and significantly
(p<0.001) reduced with the 15 days of drug treatment. This prevailed that
extracts had greater effect in the food
intake and body weight. Furthermore, the lipid profile was carried out that showed good level of significance (p<0.001; p<0.05) of
for total cholesterol, triglyceride, HDL and LDL levels. Thus, the drug proved to be significant in the lipid lowering
effect relating to obesity. To conclude, the
can be used as a potential herbal source for anti-obesity activity.
can serve as potential herbal drug which is already explored for anti-diabetic activity, has proved
to be a potential anti-obesity activity.
Devang Y Shelat has completed his M. Pharm at the age of 23 years from Nirma University, 2012 and B. Pharm from B.S. Patel Pharmacy College,
2010. He had formulated and developed Herbal and Synthetic Shampoo for Larmose Company situated at Ahmedabad, Gujarat, India. Presently,
been a research associate with Lacgene Pvt. Ltd., Surat, Gujarat, India. Has done collaborative research with Green Chem, Banglore, Karnataka,
India for anti-obesity activity.
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