Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Background: The paleolithic diet, devoid of food-processing procedure, is more satiating and produces a greater weight loss than recommended diets, but seems impossible to implement in our modern times where refined food is dominant. We investigated in humans whether by excluding only few refined foodstuffs implicated in obesity, it was possible to overcome the limited food choices of the paleolithic diet, but still restore early satiety and the subsequent weight loss. Methods: In this 2-year prospective study, we assigned 105 overweight subjects (mean age 50, mean BMI 30.5 Kg/m², 39% with type 2 diabetes) to an ad-libitum diet that excludes 6 refined foodstuffs (margarine, vegetable oils, butter, cream, processed meat, and sugary drinks) called the “1,2,3 diet”. Professional contact was minimal. The primary outcome was the change in body weight. Results: At 2 years, participants had lost an average of 4.8 kg (p<0.001), which represents 5.6% of their initial body weight. Among completers (51%), the average weight loss was 5.5 kg (p<0.001), 56% and 22% had a reduction of at least 5% and 10% of their initial body weight respectively. 82% of participants adhered to the diet. Among diabetics, weight loss was similar to non-diabetics, the mean HBA1C level decreased by 1% (p=0.001) Conclusions: The 1,2,3 diet produces a long-term weight loss similar to high-intensity intervention diets. Avoiding 6 refined food items rather than counting calories, fat, carbohydrate or protein, appears to be a cost-effective approach. Larger controlled studies are required.

Biography

Email: rodicourie@gmail.com