alexa Obesity As A Metabolic Disorder Regulated By Insulin: Childhood Obesity Largely Free From Insulin Resistance Would Be Treated Easily By Carbohydrate Restriction
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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JOINT EVENT 10th International Conference on Childhood Obesity and Nutrition & 2nd International Conference on Metabolic and Bariatric Surgery
June 12-13, 2017 Rome, Italy

Song Jae Lee and Sang Won Shin
Chungnam National University, South Korea
Korea University, South Korea
Posters & Accepted Abstracts: J Obes Weight Loss Ther
DOI: 10.4172/2165-7904-C1-046
Abstract
Statement of the Problem: Most previous researches on obesity are based on the premise that obesity is simply caused by imbalance between calorie intake and expenditure and thereby, metabolism involved in obesity is almost ignored. As a result, we have no consensus yet on the cause of the obesity. Methodology & Theoretical Orientation: We have reviewed the basics of the metabolism and physiology behind the fat accumulation in the fed state and fat mobilization in the fasted state in healthy individuals without any sign of insulin resistance—most children would be metabolically healthy. Findings: The postprandial hyperglycemia and subsequent postprandial hyperinsulinemia induced when relying on CRD would enhance fat accumulation in the fed sate. Postprandial hyperinsulinemia would then transition to basal hyperinsulinemia—a relatively low level of insulin in the fasted state—and not only inhibit lipolysis, lowering the level of plasma acids, but also suppress hepatic glucose production (HGP), lowering the level of plasma glucose. The enhanced fat accumulation in the fed state combined with limited lipolysis in the fasted state would lead to net weight gain. Furthermore, the low level of plasma fatty acids and glucose— the energy fuel—in the fasted state is likely to induce intense hunger and physiological weakness, which are in turn likely to induce overfeeding and physical inactivity, respectively, leading to positive energy balance and eventual obesity. Conclusion & Significance: Obesity is a metabolic disorder proceeding in the physiological condition of hyperglycemia and subsequent hyperinsulinemia induced when relying on CRD. Healthy obesity exhibiting no sign of insulin resistance yet, frequently observed in children would be treated relatively by carbohydrate restriction or more specifically by reliance on fat rich diet (FRD).
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