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Adipose tissue plays important role in human body, not only as the energy
storage organ, but also as the endocrine organ. In obesity, the profile of secreted
adipokines/cytokines and the whole metabolism of adipose tissue are changing.
Metabolic disorders induced by obesity are characterized by severe aberration
in expression rates of numerous genes important for metabolism regulation. It
has been speculated that changes might be driven by epigenetic regulation like
DNA methylation or histone modifications. Numerous data implicate obesity
with DNA hypermethylation. Similarly, a body of literature documented role
of histone modifications in obesity-induced metabolic disorders, thought, most
results concern animal???s models. In present study, we analyzed the influence of
obesity on the global DNA methylation and expression of main genes encoding
epigenetic modifying enzymes in human adipose tissue in two various fat depots:
visceral (VAT) and subcutaneous (SAT) adipose tissues. Our preliminary results
showed that the global DNA methylation was increased in obese individuals,
both in SAT and VAT. Furthermore, we found differences in expression profile
between SAT and VAT of numerous genes including HDAC1, SLC2A4, PTPN1,
SCD-1, IL-6 and more related to insulin sensitivity, lipids profile and adipokines/
cytokine secretion and what???s more expression rate of numerous genes displayed
correlation with obesity, glucose and/or cholesterol. Finally, we were searching for
the cause of different genes expression profile, for that reason we investigated the
methylation pattern of gene???s promoters and histone modifications by chromatin
immunoprecipitation. Obtained results suggest that obesity might influence
epigenome and thus induce changes in adipocytes metabolism.
Malgorzata Malodobra-Mazur has completed her PhD in 2010 year from Wroclaw Medical University, Wroclaw, Poland and Post-doctoral studies from Nencki Institute of Experimental Biology, Warswa, Poland. Furthermore, she performed an Internship at Joslin Diabetes Center, Harvard Medical School, Boston, USA. She is a Principal Investigator of two scientific grants funed by National Science Center, Poland and Nutricia Fundation, Poland. She has published more than 10 papers in reputed journals.