Preventive Effects Of Fangfengtongsheng Pill On Obesity Through Energy Consumption And Antiinflammatory Effect | 36269
Journal of Obesity & Weight Loss Therapy
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Introduction: N-truncated form of peroxisome proliferator-activated receptor-γ coactivator-1α (NT-PGC-1α) is a novel
truncated form of PGC-1α and contains core functional areas of PGC-1α. NT-PGC-1α had become a new target for obesity
treatment which plays an important role in compensation and substitution of PGC-1α. Fangfengtongsheng (FFTS) pill is
a traditional Chinese medicine which has anti-obesity effect and is composed of seventeen strains of herbs. However, the
mechanism is not clear.
Objective: To investigate the anti-obesity mechanism of FFTS from the energy metabolism and the anti-inflammatory effect.
Material and methods: High-fat diet induced obese ICR mouse and brown adipose tissue primary cell were used to study the
energy metabolism pathway and Raw264.7 cell was used to explore the anti-inflammatory effect.
Results: Our results indicate that FFTS pill has a potential to improve the gene expression of PGC-1α, NT-PGC-1α and UCP1
to increase energy expenditure, meanwhile exhibits a great reduction of TNF-α,IL-6,IL-1β and iNOS expression to alleviate
Conclusion: FFTS pill has a therapeutic effect on obesity through the promotion of energy consumption and inhibition of
pro-inflammatory genes expression.
Yingying Chen has completed her bachelor degree at the age of 23 years from Henan University of TCM and fortunately became a candidate in the Master-PhD program of China pharmaceutical University in September 2013. Her research focuses on obesity and other metabolic diseases.