Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Introduction: N-truncated form of peroxisome proliferator-activated receptor-�?³ coactivator-1�?± (NT-PGC-1�?±) is a novel truncated form of PGC-1�?± and contains core functional areas of PGC-1�?±. NT-PGC-1�?± had become a new target for obesity treatment which plays an important role in compensation and substitution of PGC-1�?±. Fangfengtongsheng (FFTS) pill is a traditional Chinese medicine which has anti-obesity effect and is composed of seventeen strains of herbs. However, the mechanism is not clear. Objective: To investigate the anti-obesity mechanism of FFTS from the energy metabolism and the anti-inflammatory effect. Material and methods: High-fat diet induced obese ICR mouse and brown adipose tissue primary cell were used to study the energy metabolism pathway and Raw264.7 cell was used to explore the anti-inflammatory effect. Results: Our results indicate that FFTS pill has a potential to improve the gene expression of PGC-1�?±, NT-PGC-1�?± and UCP1 to increase energy expenditure, meanwhile exhibits a great reduction of TNF-�?±,IL-6,IL-1�?² and iNOS expression to alleviate inflammation reaction. Conclusion: FFTS pill has a therapeutic effect on obesity through the promotion of energy consumption and inhibition of pro-inflammatory genes expression.

Biography

Yingying Chen has completed her bachelor degree at the age of 23 years from Henan University of TCM and fortunately became a candidate in the Master-PhD program of China pharmaceutical University in September 2013. Her research focuses on obesity and other metabolic diseases.

Email: cmcy919925@126.com