There is growing recognition of the importance of nutritional factors in the maintenance of bone and joint health
and that nutritional imbalance combined with endocrine abnormalities may be involved in the pathogenesis of Osteoarthritis
The present study sought to identify influence of dietary nutrients in prevalence of Osteoarthritis (OA) knee
150 Subjects were recruited in this case control study from outpatient clinic with the diagnosis of knee Osteoarthritis
(KOA) according to the criteria of American College of Rheumatology (ACR). Controls were age sex matched healthy subjects
who were free from disease under study. OA was radiologically graded according to Kellgren-Lawrence (KL) grades. Body Mass
Index (BMI) was recorded by standard procedure. Dietary nutrient intakes were analyzed by self administered questionnaire
including three day dietary recall and food frequency table (FFQ).
An average weight and BMI was significantly higher in subjects with OA knee in comparison to subjects without KOA.
Among all dietary factors under study riboflavin, β-carotene, vitamin C and vitamin D was significantly lower in subjects having
OA knee in comparison to subjects without OA knee. In unadjusted logistic regression, lower intake quartile of riboflavin,
β-carotene, vitamin C and vitamin D having higher risk of OA knee in comparison to higher intake quartiles. However in
adjusted analysis, risk of OA knee for riboflavin was diminished and β-carotene lose some strength but vitamin C and D having
similar strength of risk of OA knee in quartile having lower intake. As the severity of disease was only defined by vitamin D intake.
The present cross sectional study revealed that lower intake of β- carotene, vitamin C and vitamin D intake is
risk factor for knee OA. These nutrients might be an explanatory nutrient for the course of OA knee and might lead to disease
Divya Sanghi holds M.Sc. in Nutrition and PhD at CSM Medical University, Lucknow, India. From the inception of her PhD in 2006 until completion,
her research was funded by the State Council of Science and Technology, first as JRA and later as SRA. Presently she is working as SRF of Indian
Council of Medical Research. Her research is centered on osteoarthritis knee and the dietary/nutritional factors contributing its risk. Her current
primary research concerns the association of VDR gene polymorphism and the role of vitamin D in the incidence and progression of OA knee. She
has published four research articles and a review in a range of journals.
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