Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Background: Testosterone (T) and obesity are inversely associated. Obesity has a greater impact on T decrease than advancing age.
Methods: Single-center, prospective, cumulative registry study of 340 hypogonadal men (total T ≤12.1 nmol/L and presence of
symptoms). 237 men with obesity class I-III were analyzed. All men received TU injections every 3 months for up to 7 years.
Anthropometric parameters were measured at every 3-monthly visit.
Results: Class I (n=103, mean age: 58 years): Weight decreased from 102.79 to 85.41 kg by 17.27 kg, per cent change from baseline
-16.71%. Waist circumference (WC) decreased from 104.74 to 95.24 cm by 8.93 cm. BMI decreased from 32.85 to 27.65 kg/m2 by
5.5 kg/m2. Class II (n=97, mean age: 60 years): Weight decreased from 116.67 to 92.19 kg by 25.15 kg, per cent change from baseline
-21.52%. WC decreased from 111.97 to 100.96 cm by 12.53 cm. BMI decreased from 37.33 to 29.88 kg/m2 by 8.06 kg/m2. Class III
(n=36, mean age: 60 years): Weight decreased from 128.92 to 100.75 kg by 29.3 kg, per cent change from baseline -22.79%. WC
decreased from 117.56 to 103.63 cm by 12.93 cm. BMI decreased from 41.99 to 33.23 kg/m2 by 9.59 kg/m2. No patient gained or
re-gained weight. No patient dropped out. There were no major adverse cardiovascular events during the entire observation period.
Conclusions: All changes were clinically meaningful and sustained for the full observation period. T therapy is an effective approach
to achieve sustained weight loss in obese hypogonadal men, thereby potentially reducing cardiometabolic risk.

Biography

Farid Saad worked for various Pharmaceutical companies as specialist for reproductive endocrinology, pediatric endocrinology, andrology, endocrinology of male ageing,
and hormonal male contraception in clinical development andrology, scientific and medical affairs. He currently works for Bayer Pharma in Berlin, Germany. He has authored
and co-authored more than 100 peer-reviewed papers and more than 500 scientific abstracts. He received honorary Professorships in clinical research and endocrinology
at Gulf Medical University, Ajman, UAE, and at Men’s Health Reproduction Study Center, Hang Tuah University, Surabaya, Indonesia.