Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Statement of the Problem: Among the causes of obesity an important role is played by the heredity. The FTO is one of the genes associated with obesity and body mass fat. And polymorphism rs9939609 of this gene located in the first intron (the code is W=A/T) appears the most significant. Methodology & Theoretical Orientation: The study included total of 128 Caucasian female adolescents (average age 15.86�?±1.02) living in Eastern Siberia (Irkutsk region, Russia). SDS BMI, % of body mass fat was measured. 59 girls were included in group with normal weight (SDS BMI 0.84�?±0.55) and 69 girls were included in group with overweight and obesity (SDS BMI 2.52�?±0.72). Genomic DNA was extracted from EDTA-treated whole blood by commercial kits (DNA-Sorb-B, AmpliSens, Russia). Genotyping of the FTO rs9939609 was performed using polymerase chain reaction in real time with DT-Prime cycler (DNA-technology, Russia). Statistical analysis was performed by soft â�?�?STATISTICA8.0â�?. Findings: A-allele frequency was 40% in control group and 49% was in group with overweight and obesity (�?�?=0.223). Comparisons of SDS BMI and percent of body mass fat stratified by FTO rs9939609 genotypes are shown in table 1. We found the significant increase of SDS BMI in carriers of A-allele in group with overweight and obesity. There is no association in group with normal weight. Conclusion & Significance: Thus, carrier of the A-allele of FTO rs9939609 are associated with higher meaning of SDS BMI in female adolescents with overweight and obesity, living in Eastern Siberia.

Biography

Tatyana Bairova completed her graduation at Tomsk Medical Universitety as a pediatrician and; post-graduation at Scientific Centre for Family Health and Human Reproduction Problems (SC FHHRP, Irkutsk, Russian Federation) where she is a specialist and a researcher.

Email: tbairova38@mail.ru