Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Obesity is a recognized risk factor for cardiovascular disease, diabetes, and hypertension. Adipose tissue secretes numerous
proinflammatory cytokines, chemokines, and adipokines. Furthermore, obesity was also correlated with depression and the
possible mechanism remains unclear. Epicardial adipose tissue (EAT) induces activated inflammatory cells secreting cytokines,
including soluble CD40 ligand (sCD40L). In turn the serums CD40L can trigger inflammatory responses. We initiated a prospective
weight reduction study in men with metabolic syndrome and try to elucidated the effect of weight loss on epicardial fat thickness and
insulin resistance, mechanism exploration of depression and (Brain-derived neurotrophic factor) BDNF, and its associative changes
of cytokines, like paraoxonase-1, monocyte chemoattractant protein-1 (MCP-1), serum cystatin C, urinary N-acetyl glucosaminidase
(NAG) and its indicative clinical significances. We also elucidated that different area of EAT thickness, examined by MRI, has different
clinical significance and relationships with cytokines.

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