alexa
Reach Us +44 330 818 7254

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
The Role Of Hepatic Rho-kinase In Regulating Glucose And Lipid Homeostasis | 36322
ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Recommended Conferences

25th Global Obesity Meeting

Rome, Italy

19th Euro Obesity and Endocrinology Congress

Barcelona, Spain
Google Scholar citation report
Citations : 1582

Journal of Obesity & Weight Loss Therapy received 1582 citations as per Google Scholar report

Journal of Obesity & Weight Loss Therapy peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • Centre for Agriculture and Biosciences International (CABI)
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • CABI full text
  • Cab direct
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • University of Bristol
  • pubmed
Share This Page

The role of hepatic rho-kinase in regulating glucose and lipid homeostasis

3rd International Conference and Exhibition on Obesity & Weight Management

Hu Huang

East Carolina Diabetes and Obesity Institute, USA

Accepted Abstracts: J Obes Weight Loss Ther

DOI: 10.4172/2165-7904.C1.022

Abstract
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with obesity and insulin resistance and ultimately leads to cirrhosis and other complications. However, the pathogenesis of this disease has not yet been fully understood. In our studies, mice with liver-specific Rho-kinase 1 (ROCK1) deletion were used to examine role of ROCK1 in regulating hepatic glucose homeostasis and lipid metabolism. Our results show that hepatic ROCK1-deficiency leads to reduced body weight, improved insulin sensitivity and hepatic steatosis in diet-induced obese mice. These changes are associated with a decreased lipogenic rate in the ROCK1-deficient primary hepatocytes compared to control hepatocytes using 14C-lactate as a lipogenic substrate. These data are further supported by the experimental evidence that ROCK1 deletion in the liver causes a significant suppression in expression of key lipogenic enzymes, including FAS, SCD1, Elovl2 and SREBP-1c. In addition, the up-regulation of hepatic ROCK1 expression and activity and hepatic steatosis induced by a high-fat diet are greatly reduced after metformin treatment. Consistent with the in vivo data, treating hepatocytes with metformin markedly reduces ROCK1 expression and activity in a dose-dependent manner and decreases expression of lipogenic enzymes and the rate of de novo lipogenesis. Collectively, these data identify hepatic ROCK1 as a key regulator of fat metabolism and further demonstrate that inhibition of hepatic ROCK1 could be a novel therapeutic approach for the treatment of NAFLD.
Biography

Hu Huang has completed his PhD from University of Tsukuba, Japan and postdoctoral studies from Beth Israel Deaconess Medical Center and Harvard Medical School. He has published more than 15 papers in reputed journals and serving as an editorial board member of repute. He is assistant professor at East Carolina Diabetes and Obesity Institute & East Carolina University. His laboratory seeks to understand basic molecular mechanisms underlying the metabolic syndrome, including obesity, insulin resistance, impaired glucose metabolism and non-alcoholic fatty liver disease.

Email: [email protected]

Top