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To investigate the influence of polymorphisms in PRDM16 and PDE4D genes which are involved in thermogenesis process on obesity and blood lipids profile in Saudi population
17th International Conference on Obesity, Diet and Nutrition
Aisha Alamrani
Tabuk University, Saudi Arabia
Posters & Accepted Abstracts: J Obes Weight Loss Ther
Abstract
Aim: The aim of this study was to investigate the influence of polymorphisms in PRDM16 and PDE4D genes which are involved in thermogenesis process on obesity and blood lipids profile in Saudi population. Methods: A case control format was used that involved 89 obese individual and 84 non-obese (control). The PRDM16 (rs2651899) and PDE4D (rs295978) polymorphisms were genotyped using KASPTM (Competitive Allele-Specific PCR) method. Results: Participants with the mutated genotypes, AA and AG, of PRDM16 (rs2651899) polymorphism were significantly more likely to be obese as compared to participants with wild type genotype (OR=21, 95% CI=5.4190 to 84.4231, P value<0.0001 and OR=44.6, 95% CI=11.5984 to 172.0157, P value<0.0001, respectively). This polymorphism found to be significantly affecting the participants blood lipids profiles. In contrast, PDE4D (rs295978) polymorphism was not associated with risk of obesity and had no effects on blood lipids profile. Conclusions: We found that the PRDM16 polymorphism (rs2651899) is a risk factor for obesity and influence blood lipids profiles significantly in Saudi population. While the PDE4D (rs295978) polymorphism didn’t show significant effect on risk of obesity or blood lipids profiles.Biography
E-mail: aiashah_atiah@hotmail.com
