Depolymerization And Oxidative Degradation Of Poly (ethylene Oxide) | 26818
Journal of Pain & Relief
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Prescription medications resistant to abuse and misuse are often made to resist mechanical methods of crushing. Polyethylene
oxides (PEO) of high molecular weight have become popular excipients for such applications using thermal processes to
achieve crush resistance. However, abusers have found both in the literature and on the internet that PEO can lose its abuse
deterrent properties through degradation when exposed to UV light or high temperatures. The primary objective of this study
was to determine the effect of high temperatures and air environment on the degradation of polyethylene oxide. Commercial
grades of PEO (Polyox? WSR) were selected for study and include, N60 k, 301, coagulant, and 303 having respective average
molecular weights of 2 million, 4 million, 5 million and 7 million.Measurements of thermal degradation were investigated
by thermo gravimetric analysis (TGA) in combination with differential thermal analysis (DSC). Results were obtained in the
temperature ranges of 25-445oC for DSC (Perkin Elmer DSC 4000) and between 30-500oC for TGA (Perkin Elmer TGA 4000)
at a rate of 10oC/min while under a nitrogen or room air atmosphere (20 mL/min). In air the depolymerization temperature
ofN60k, 301, coagulant and 303 was 195.22, 194.91, 191.78 and 192.12oC, respectively. The inflection pointsobtained from
TGA curves were295.99, 294.75, 293.89 and 293.15oC, respectively. On the other hand no depolymerization was observed
under nitrogen conditions and inflection points were obtained at much higher temperatures, 415.6, 416.1, 414.4 and 416.69oC,
respectively.It was concluded that polyethylene oxide is unstable at higher temperatures under normal air conditions and
therefore anti-oxidant should be considered for formulation stability and preservation of abuse deterrent features.
Srinath Muppalaneni earned a BS in Pharmacy from Andhra University and a MS in Pharmaceutical Sciences from Campbell University. He is currently a Doctoral
candidate in Pharmaceutics at Nova Southeastern University (NSU) with dissertation research focusing on abuse-deterrent formulations. David Mastropietro
received his BS in Pharmacy from Massachusetts College of Pharmacy and Ph. in Pharmaceutics from NSU. Hossein Omidian has an MSc in Chemical Engineering
and a PhD in Polymer Science. He is currently an Associate Professor at NSU and leads the research group in Advanced Pharmaceutical Dosage.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals