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Simons J | OMICS International
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Simons J


Detection of IDH1 and IDH2 Mutations in Patients with Acute Myeloid Leukemia Using Novel, Highly Sensitive Real-Time PCR Assays with Rapid Turnaround Time

Isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations are frequent in acute myeloid leukemia (AML). Here we describe the qualitative polymerase chain reaction (PCR)-based Abbott Realtime IDH1 and IDH2 assays, which detect single nucleotide variants coding for five IDH1 and nine IDH2 mutations. We evaluated the sensitivity and specificity of the Ab... Read More»

Dash DP, Wise L, Knier A, Boretsky M, Simons J, Berchanskiy D, Indig MA and Joseph AM

: J Mol Genet Med 2019, 13: 421

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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