alexa Lynch syndrome | Israel| PDF | PPT| Case Reports | Symptoms | Treatment

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Lynch Syndrome

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  • Lynch syndrome

    Pathophysiology
    Lynch syndrome is the familial clustering of colorectal and endometrial cancers. This syndrome is passed in an autosomal dominant fashion within families with defective mismatch repair as the genetic basis for cancer development in these patients.

  • Lynch syndrome

    Statistics
    To report gene distribution, mutations detected and co-occurrence of related syndromes in a cohort of Ashkenazi Jews in Israel. Patients were identified in dedicated high risk clinics in 3 medical centers in Israel. Diagnostic process followed a multi-step scheme. It included testing for founder mutations, tumor testing, gene sequencing and MLPA

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