alexa A Study On The Antimicrobial Activity Of New Substitute
E- ISSN: 2320 - 3528
P- ISSN: 2347 - 2286

Research & Reviews: Journal of Microbiology and Biotechnology
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Research Article

A Study On The Antimicrobial Activity Of New Substituted 1,3,4-Oxadiazole Analogues

Jayaroopa Prabhashankar1, Ajay Kumar Kariyappa1*, Deepa Nagaraju2 and Raghavendra Maddur Puttaswamy2
  1. Post Graduate Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore, Karnataka, India
  2. Post Graduate Department of Microbiology, Maharani’s Science College for Women, JLB Road, Mysore, Karnataka,India
Corresponding Author: Post Graduate Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore, Karnataka, India. Mobile: +91 9972829045
Received: 06/06/2013 Accepted: 18/06/2013
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Abstract

Substituted 1,3,4-oxadiazole derivatives such as 2-(chloromethyl)-5-heptadecyl-1,3,4-oxadiazole (4a), 2-benzyl-5-heptadecyl-1,3,4-oxadiazole (4b), 2-heptadecyl-5-phenyl-1,3,4-oxadiazole (4c), 2-heptadecyl-5-styryl-1,3,4-oxadiazole (4d), 2-(5-heptadecyl-1,3,4-oxadiazol-2-yl)phenol (4e), 2-heptadecyl-5-o-tolyl-1,3,4-oxadiazole (4f), 2-heptadecyl-5-(4-nitrophenyl)-1,3,4-oxadiazole (4g) and 4-(5-heptadecyl-1,3,4-oxadiazol-2-yl)benzenamine (4h) were subjected to antibacterial and antifungal activity assay by cup diffusion and poisoned food technique against Escherichia coli, Staphylococcus aureus and three strains of seed borne toxigenic Fusarium verticilloides isolated from maize (Zea mays L.) and paddy (Oryza sativa L.). F. verticilloides was confirmed by species specific primers VERT 1 and VERT 2 and fumonisin producing ability was confirmed by VERTF-1 and VERTF-2 using polymerase chain reaction. All the compounds were tested at different concentration (25 to 100 ppm). The results revealed that all eight oxadiazoles completely inhibited all the strains of toxigenic F. verticilloides at 100 ppm indicating Minimal Inhibitory Concentration (MIC). 4b recorded highly significant antibacterial activity against E. coli where as it was 4f against Staph. aureus. The study is successful in reporting the antimicrobial activity of the oxadiazoles and its possible application in management of seed borne fumonisin producing fungi and also bacterial infection in human.

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