ANTIPYRETIC ACTIVITY OF METHANOL EXTRACT OF ACACIA LEUCOPHLOEA ROXB BARK
Rajesh Gupta1*, Arun Kumar2, Aiswarya G3, Jagdesh Singh4
|Corresponding Author: Rajesh Gupta, E-mail: [email protected]|
The plant Acacia leucophloea Roxb is reported to have great medicinal value in Indian medicine. The present study deals with the preliminary phytochemical screening of Acacia leucophloea Roxb, in vivo evaluation of antipyretic activity of methanol extract by using yeast-induced pyrexia method. The effect of methanol extract of Bark shows that different dose caused lowering of the body temperature up to 2 h following its administration. The effect of methanol extract on yeast-induced pyrexia shows that the rectal temperature was markedly elevated to 38.24°C, 24h after the subcutaneous injection of yeast suspension, decreased to 37.97°C within 30 minutes of Bark extract (100mg/kg) treatment respectively. Bark extract are producing significant antipyretic activity against the yeastinduced pyrexia model, hence the extract favours antipyretic activity.