alexa Pharmaceutical Evaluation of Type II Oral Antidiabetic

Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Pharmaceutical Evaluation of Type II Oral Antidiabetic Agent

To read the full article Peer-reviewed Article PDF image


In this study, the pharmaceutical evaluation including physical and chemical evaluation of commercial Glibenclamide tablets (Gliboral®, Glynase® and Glib-5®) that are available in the Libyan market was performed according to the British Pharmacopoeia (BP) monograph (2009). The obtained results from this work indicated that, significant differences in the dissolution behavior were observed between the different tested commercial products. Gliboral® exhibited the lowest dissolution profile while the other products showed dissolution profiles that were almost twice that of Gliboral®. However, no significant differences were observed for the percentage (%) of weight loss (friability) and disintegration time for the tested products with % RSD value of less than 2 %. Additionally, all products were found satisfactory in terms of identification using infrared (IR) spectroscopy in comparison to reference spectra. Moreover, the assay results for the % content of glibenclamide using high performance liquid chromatography (HPLC) showed that all tested products were found to pass and satisfied with the BP specifications which required glibenclamide content to be within the range of 95 to 105 % of the labeled content. The precision of the analysis was also evaluated and calculated and the results showed good precision (interday and intraday) with % RSD value of less than 1.9 % (based on 6 injections).


Recommended Journals

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version