alexa Positive Effect of Impairment-Oriented Training on N-Acetylaspartate Levels of Ipsilesional Motor Cortex in Subcortical Stroke: A Case Study
ISSN: 2329-9096

International Journal of Physical Medicine & Rehabilitation
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Positive Effect of Impairment-Oriented Training on N-Acetylaspartate Levels of Ipsilesional Motor Cortex in Subcortical Stroke: A Case Study

Ali Bani Ahmed1-3 and Carmen M Cirstea1,2,4*

1Departments of Physical Therapy & Rehabilitation Science, Hoglund Brain Imaging Center, USA

2Department of Neurology, University of Kansas Medical Center, Missouri, USA

3Department of Physical Therapy, University of Tabuk, Saudi Arabia

4Department of Physical Medicine & Rehabilitation, University of Missouri, Columbia, USA

*Corresponding Author:
Carmen M. Cirstea
Department of Physical Medicine & Rehabilitation
University of Missouri, One Hospital Drive
DC046.00, Columbia, MO 65212, USA
Tel:
573-884-8792
Fax: 573-884-4540
E-mail:
[email protected]

Received Date: December 11, 2015 Accepted Date: January 29, 2016 Published Date: February 01, 2016

Citation: Ahmed AB, Cirstea CM (2016) Positive Effect of Impairment-Oriented Training on N-Acetylaspartate Levels of Ipsilesional Motor Cortex in Subcortical Stroke: A Case Study. Int J Phys Med Rehabil 4:325. doi: 10.4172/2329-9096.1000325

Copyright: © 2016 Ahmed AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and Purpose: We investigated the effects of an intensive impairment-oriented training on neuronal state (assessed by proton MR spectroscopy, 1H-MRS) of the spared motor and premotor cortices in the injured (ipsilesional) hemisphere and clinical impairment in a patient with chronic subcortical stroke. Methods: One survivor of a single ischemic stroke located outside of the motor and premotor cortices (assessed on T1-weighted MRI) was studied at six months after stroke. We used functional MRI-guided 1H-MRS to quantify the levels of N-acetylaspartate (NAA - a putative neuronal marker) in the hand representation within ipsilesional primary motor cortex (M1), dorsal premotor cortex (dPM) and supplementary motor area (SMA), and Fugl-Meyer (normal=66 points) test to assess the arm motor impairment immediately before and after a motor training paradigm. Training comprised intensive variable practice (1080 repetitions over 12 day-period) of a reach-to-grasp task with the impaired hand while focusing the learner’s attention on an altered movement component, i.e., decreased elbow extension. Results: At baseline, the patient was severely impaired (Fugl-Meyer score=25 points) and exhibited lower level of NAA in all areas (M1, 9.2 mM vs. 11.6 ± 2.0 mM in healthy controls; dPM, 8.9 mM vs. 12.2 ± 1.9 mM; SMA, 7.4 mM vs. 11.0 ± 2.3 mM). After training, the patient improved clinically (by 6 points) and displayed higher levels of NAA across all areas (by 0.6-3.3 mM). Conclusions: Our data demonstrated that the radiologically normal-appearing ipsilesional motor and premotor areas have the resources to boost behavioral output in response to an intervention. We hope that these data will act as a starting point for further research to test the potential of 1H-MRS measures to provide a biomarker of neuroplasticity in response to restorative therapies in chronic stroke.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords