alexa Synthesis and Anticoagulant Activity of C3- and O-alkylated 4-Hydroxycoumarin Derivatives
e-ISSN: 2319-9849

Research & Reviews: Journal of Chemistry
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Synthesis and Anticoagulant Activity of C3- and O-alkylated 4-Hydroxycoumarin Derivatives

Venugopalarao Narayana1 Ravi Varala2*, Vijay Kotra3, and PK Zubaidha1

1School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra- 431 606, India

2Department of Chemistry, Rajiv Gandhi University of Knowledge Technologies, AP-IIIT, Basar, Adilabad, Andhra Pradesh- 504 107, India

3Department of Pharmacy, Acharya Nagarjuna University, Guntur, Andhra Pradesh- 522 510, India

*Corresponding Author:
Ravi Varala
Department of Chemistry
Rajiv Gandhi University of Knowledge Technologies
AP-IIIT, Basar, Adilabad
Andhra Pradesh- 504 107, India
Tel: +91 9618286529

Received date: 29/10/2012; Revised date: 03/02/2013; Accepted date: 09/02/2013

 

Abstract

C3- and O-alkylated 4-hydroxycoumarin derivatives synthesized from reusable solid superacid catalyst, namely, sulfated tin oxide (STO) in acetic acid under reflux conditions with good yields and well characterized by IR, 1H/13C NMR and mass spectrometry. The synthesized compounds were evaluated for anticoagulant activity. Among the compounds tested for anti-coagulant activity, compounds 3b, 3c, 3d and 3g showed significant activity compared to that of standard.

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