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The Roles Of Human Apurinic/ Apyrimidinic Endonuclease/redox Effector Factor (APE1/Ref-1) In Tumor Diagnosis And Related Mechanism Study | 3662

Journal of Molecular Biomarkers & Diagnosis
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The roles of human apurinic/ apyrimidinic endonuclease/redox effector factor (APE1/Ref-1) in tumor diagnosis and related mechanism study

2nd World Congress on Biomarkers & Clinical Research

Nan Dai

ScientificTracks Abstracts: J Mol Biomark Diagn

DOI: 10.4172/2155-9929.S1.2

Apurinic/apyrimidinic endonuclease/redox eff ector factor (APE1/Ref-1) is the major AP endonuclease in mammalian cells. It is a multifunctional protein which functions not only in DNA repair but also as a reduction-oxidation factor. Recently studies have showed that alteration of expression levels, cellular location and/or patterns of APE1/Ref-1 may consider as a good candidate in cancer screening and auxiliary diagnosis. Interestingly, we found that expression of APE1/Ref-1 was signifi cantly increased in tumor patients? serum. So we measured serum APE1/Ref-1 protein level in 210 healthy and 200 lung cancer patients by sandwich ELISA. Serum APE1/Ref-1 protein level was skewed distribution and signifi cant increased in cancer patients (P<0.05). We also detected serum APE1/Ref-1 antibody in 345 lung cancer patients, 350 healthy donors and 91 monitor patients before and aft er chemotherapy by indirect ELISA. Serum APE1/Ref-1-Abs level of lung cancer patients was signifi cantly higher than that of healthy donors and aft er chemotherapy (P=0.000). Both of APE1/Ref-1 protein and antibody combined with CEA, CA125 and CA242 can elevate the diagnostic sensitivity and correct rate. Th ese results indicated that detection of APE1/Ref-1 in serum may be helpful in early diagnosis of malignant tumors and evaluating chemosensitivity. To explore the genetic association between SNP of APE1/Ref-1 and lung cancer susceptibility, we investigated a population based case control study among Chinese Han people in Chongqing City. Logistic regression analysis indicated that APE1 -141G/G genotype were reduced 38% risk of lung cancer compared with APE1 -141T/T genotype. APE1-141T/148Glu haplotype may serves as an important genetic susceptibility factor for lung cancer.
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