alexa
Reach Us +44-1904-929220
The Roles Of Human Apurinic/ Apyrimidinic Endonuclease/redox Effector Factor (APE1/Ref-1) In Tumor Diagnosis And Related Mechanism Study | 3662
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

The roles of human apurinic/ apyrimidinic endonuclease/redox effector factor (APE1/Ref-1) in tumor diagnosis and related mechanism study

2nd World Congress on Biomarkers & Clinical Research

Nan Dai

ScientificTracks Abstracts: J Mol Biomark Diagn

DOI: 10.4172/2155-9929.S1.2

Abstract
Apurinic/apyrimidinic endonuclease/redox eff ector factor (APE1/Ref-1) is the major AP endonuclease in mammalian cells. It is a multifunctional protein which functions not only in DNA repair but also as a reduction-oxidation factor. Recently studies have showed that alteration of expression levels, cellular location and/or patterns of APE1/Ref-1 may consider as a good candidate in cancer screening and auxiliary diagnosis. Interestingly, we found that expression of APE1/Ref-1 was signifi cantly increased in tumor patients? serum. So we measured serum APE1/Ref-1 protein level in 210 healthy and 200 lung cancer patients by sandwich ELISA. Serum APE1/Ref-1 protein level was skewed distribution and signifi cant increased in cancer patients (P<0.05). We also detected serum APE1/Ref-1 antibody in 345 lung cancer patients, 350 healthy donors and 91 monitor patients before and aft er chemotherapy by indirect ELISA. Serum APE1/Ref-1-Abs level of lung cancer patients was signifi cantly higher than that of healthy donors and aft er chemotherapy (P=0.000). Both of APE1/Ref-1 protein and antibody combined with CEA, CA125 and CA242 can elevate the diagnostic sensitivity and correct rate. Th ese results indicated that detection of APE1/Ref-1 in serum may be helpful in early diagnosis of malignant tumors and evaluating chemosensitivity. To explore the genetic association between SNP of APE1/Ref-1 and lung cancer susceptibility, we investigated a population based case control study among Chinese Han people in Chongqing City. Logistic regression analysis indicated that APE1 -141G/G genotype were reduced 38% risk of lung cancer compared with APE1 -141T/T genotype. APE1-141T/148Glu haplotype may serves as an important genetic susceptibility factor for lung cancer.
Biography
Relevant Topics
Top