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Review Article Open Access
Dermatitis herpetiformis (DH), or Duhring's disease, is a chronic blistering skin condition, characterised by blisters filled with a watery fluid. Despite its name, DH is neither related to nor caused by herpes virus: the name means that it is a skin inflammation having an appearance similar to herpes. DH was first described by Dr. Louis Adolphus Duhring in 1884. A connection between DH and gluten intolerance (celiac disease) was recognised in 1967, although the exact causal mechanism is not known. The age of onset is usually about 15-40, but DH can also affect children and the elderly. Men and women are equally affected. Estimates of DH prevalence vary from 1 in 400 to 1 in 10000. It is most common in patients of northern European ancestry, and is associated with the HLA-DQ2haplotype along with celiac disease and gluten sensitivity. Dermatitis herpetiformis sufferers usually experience their rashes in the same location every time. The rash might be continuous, or it might come and go. Before the actual dermatitis herpetiformis rash breaks out, your skin may itch in that location, or it might feel as if it's burning. The rash itself usually includes reddened skin plus multiple small, pimple-like bumps, which contain a clear liquid. The dermatitis herpetiformis bumps usually take several days to heal (during which time new bumps usually appear nearby), and once healed, will leave behind small purple marks that last for weeks or months. People with long-standing dermatitis herpetiformis usually have continuously reddened skin where their rash occurs. Dermatitis herpetiformis, an itchy, stinging, blistering skin rash, occurs when your skin reacts to gluten antibodies circulating in your system. Some people call dermatitis herpetiformis a "gluten rash" or a "celiac disease rash" because it occurs in conjunction with celiac disease. The purpose of present review is to summarize pathophysiology, clinical manifestations, diagnosis and treatment of dermatitis herpetiformis.
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Author(s): Jiguru Prasant