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Research Article Open Access
The present was study aimed at evaluating the antibacterial, anthelmintic and cardiotonic potentials of aqueous and ethanolic extracts of dried fruits of Aegle marmelos. Phytochemical tests on both extracts and powder material was done. The antibacterial activity was evaluated by cup diffusion method against both gram positive and gram negative bacteria. The ethanolic extracts showed more antibacterial activity than the aqueous extracts. Both the extracts having good activity against Escherichia coli (18±0.16mm and 19±0.68mm) compared to standard. The minimal inhibitory concentration of the each extract was determined both by broth culture method and agar cup diffusion methods. Ethanolic extract showed least minimal inhibitory concentration of 6.25μg/ml against Escherichia coli. The minimal inhibitory concentration values showed good correlation with experimental results. The ethanolic extracts showed more anthelmintic activity compared to the aqueous extracts. 50 mg/ml solution of ethanolic extract of Aegle marmelos showed significant activity (Time for paralysis: 28.32 ± 1.02min and Time for death: 40.16 ± 0.54min) compared to the standard. The Cardiotonic activity of the extracts was studied by using calcium free ringer’s solution against isolated frog heart. The incremental doses of aqueous and ethanolic extracts were added which produces positive inotropic and negative chronotropic effects. Total experimental results supported the traditional use of Aegle marmelos for different pharmacological properties.
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Author(s): N. Sridhar, M. Raghavendra, M. N. V. Prasad, B. V. V. S. Surya Kiran, L. K. Kanthal