Metal-metal bonds in biology

Nickel-containing metalloenzymes share a number of important characteristics. All are O(2)-sensitive, with active-sites with iron and/or nickel ions coordinated primarily by sulfur ligands and two metals are juxtaposed at the \"heart\" of the active site.

General theoretical model for electron transfer reactions in complex systems

Combination of Molecular Dynamics simulation and Perturbed Matrix Method on prototypical intramolecular electron transfer illustrates the accuracy in reproducing both thermodynamics and kinetics of a process.

Lysozyme dynamics monitored by electronic circuit

Lysozyme molecule when treated with carbon nanotube FET produced stable, high-bandwidth transducer for protein motion. pH dependence of lysozyme activity arises by increasing time spent in either nonproductive rapid motions or an inactive, closed conformation.

Chiroptical switches applied in sensing and catalysis

Chiroptical switches are applied to detect analytes with high level sensitivity and in asymmetric catalysis to offer switchable stereoselectivity and also in the controlled production of either enantiomer or diastereomer at will in many organic reactions.

Catalysis of Gold Nanoparticles within Lysozyme Crystal

AuNPs within a single protein crystal of lysozyme shown to efficiently catalyze the reduction of p-nitrophenol by NaBH(4). The use of chemicals to either accelerate or inhibit the activity is also demonstrated.