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ISSN: 2167-0846

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Anatoly E Martynyuk

Anatoly E Martynyuk Anatoly E. Martynyuk, PhD
Associate Professor
Departments of Anesthesiology and Neuroscience
University of Florida
USA
Tel: 352-281-7656
Biography

Dr. Anatoly Martynyuk is a Professor of Anesthesiology and Neuroscience at University of Florida Department of Anesthesiology and a member of the McKnight Brain Institute. Dr. Martynyuk earned a Master of Science degree from Kyiv State University as well as his PhD and DSc in biophysics from Bogomoletz Institute of Physiology in Kyiv, Ukraine. Dr. Martynyuk is a neuro-biologist investigating mechanisms of developmental neuroendocrine and neurobehavioral effects of neonatal exposure to general anesthetic agents. Dr. Martynyuk’s research has been funded by the National Institute of General Medicine and National Institute of Neurological Disorders and Stroke.

Research Interest

His research interests is the mechanisms underlying the causes of epilepsy in phenylketonuria (PKU). Despite the fact that hyperphenylalaninemia is the most common biochemical cause of mental retardation in man, the cellular mechanisms that underlie impaired brain function remain unclear. His group obtained evidence that phenylalanine-caused depression of glutamatergic synaptic transmission in the brain may be a major player in etiology of PKU. The credibility and importance of this approach is evident from the publications in Molecular Psychiatry, Brain, Epilepsia. The antiglutamatergic action of phenylalanine is unique in that that it depresses functioning of glutamate synapse at multiple pre- and postsynaptic sites. Considering the polyvalent antiglutamatergic action of phenylalanine, he suggested that derivatives of phenylalanine with greater potency may be safe and efficacious neuroprotectors in conditions characterized by excessive activation of excitatory glutamatergic synaptic transmission. They tested this hypothesis using rat models of focal brain ischemia, several rodent models of epileptic seizures and sensorimotor gating deficit. The results of these studies were published in Stroke, Mol. Pharmacol., Br. J. Pharmacol and served as the experimental basis for several patents. His current research at U.F predominantly focuses on investigation of the cellular mechanisms contributing to immediate and delayed neurological, cognitive and metabolic defects caused by anesthesia with sevoflurane and isoflurane in neonatal.

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