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1978 B.Sc. Biology, Hebrew University
1983 M.Sc. Endocrinology, Technion-Israel Institute of Technology
1984 D.Sc. Pharmacology, Technion-Israel Institute of Technology
1988 Post-Doc Pharmacology, Technion-Israel Institute of Technology
1991 Post-Doc Molecular Biology and Pharmacology, School of Medicine, Washington University, Saint Louis, MO, USA
Academic Ranks and Tenure in Institutes of Higher Education.
1984-1988 Instructor of 4th year medical students.Pharmacology,Technion-Israel Institute of Technology.
1994 –2006 Teaching Fellow,Oranim, Biology,University of Haifa,
2001-2004 Senior Lecturer,faculty of Medicine, Department of Pharmacology,Technion-Israel Institute of Technology.
2004-2005 Senior Lecturer ,Neurobiology and Evolutionary and Environmental Biology,University of Haifa
2005-2008 Senior Lecture, Biology and Evolutionary and Environmental Biology,University of Haifa.
2008-present Associated Professor,Biology, Medical Sciences and Human Biology,University of Haifa
Offices in University Academic Administration
2005-2009 Member of the Teaching Committee of the Department of Evolutionary and Environmental Biology
2008-present Member of the Teaching Committee of the Department of Human Biology
2009-present Member of the Teaching committee of the Department of Biology and Medical Sciences
2010–present Head of the committee for regulation of disease promoting agents.
2010-2012 Member of the Post Doctoral Committee
2011-present Member of the Social Involvement Committee
2012-present Member of the Graduate Studies Authority Committee
2012-present Head of the Druze division in the Jewish Arab Center
Scholarly Positions and Activities outside the University
A. Establishing a start-up Biotechnology company
2001 – 2013: Founder and Scientific director of “PROLOR Biotech.”, Ltd., a start-up Biotech company established to develop Long acting proteins for clinical use. Last year the company signed an exit for $480 million.
B. Member of the Israel Council for Higher Education
2001-present Member of the Israel Council for Higher Education
2001-present Member of the Israel Council for Higher Education,Sub-committee for medical sciences, engineering and architecture
2002-2005 Member of the sub- Committee of Planning and Budgeting for Encouraging education among Arabs in Israel
2006-2011 Head of the sub- Committee of Planning and Budgeting for Encouraging education among Arabs in Israel
2001-2006 Member of the Israel Council for Higher Education Sub-committee for Universities and Academic Colleges for Education.
2006-2012 Member of the Israel Council for Higher Education Committee For Quality and Evaluation Fields of Study
2006-2012 Member of the Israel Council for Higher Education sub-Committee for Development and Academic Policy
2010 Member of the sub-committee of the Israeli Centers for Research Excellence (I-CORE)
C. Membership of scientific organizations
2012-present Member of the committee for Binational Science Foundation (BSF)
2010-present Member of the European Society of Endocrinology
2007-present Member of the European Cell death Organization (ECDO)
2005-present Member of the Israel Society of Gene Therapy
1999-present Member of the European Association for Cancer Research
1991-present Member of the Israel Endocrine Society.
1998-2010 Member of the Israel Society of Lab Medical Sciences.
1998-2000 Member of the New York Academy of Science.
D. Expert evaluator
1. 2010 – present. Expert evaluator. Member of the committee evaluating grant proposals for US-Israel Binational Science Foundation (BSF).
2. 2000-present- Expert evaluator of grants for GIF (German-Israel Foundation).
3. 2009-present- Expert evaluator of grants for the BSF (Binational Science Foundation).
E. Referee for Journals
• Frontiers in Oncology - member of the editorial board
• PLoS ONE
• British Journal of Cancer
• Cancer Letters
• Gynecologic Oncology
• Journal of Translational Medicine Research
• Molecular Diagnosis & Therapy
• Environmental Monitoring and Assessment
• Chemistry Journals
F. Referee of M.Sc. and Ph.D. Theses
• Referee of M.Sc. and Ph.D. thesis proposals submitted from:
- Department of Evolutionary and Environmental Biology, Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Israel.
- Faculty of Medicine and Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology.
- Faculty of Life sciences, Bar-Ilan University, Ramat Gan, Israel
- Faculty of Medicine and Faculty of Health Sciences, Ben Gorion University, Beer-Sheva, Israel.
- Human Genetic Laboratory, Bharathiar University, Coimbatore, India.
In my laboratory I supervise graduate students for Ph.D and for M.Sc. thesis and the recent ongoing projects related to these fields include:
1.My lab is interested in structure - function studies of Thyrotropin (TSH); identifying protein regions which are determinants for hormone specific post-translational modifications and receptor binding/biologic activity, using site-directed mutagenesis, gene fusion and mutant cell lines. Using the molecular biology techniques I will try to study the role of oligosaccharides in the structure and function of thyrotropin (TSH). This may expand our understanding in the role of oligosaccharides in the hormone function and may lead to the development of new agonists and antagonists.
2.My lab is interested in identification of pre-apoptotic factors and characterization of their molecular pathways in human cancer cells. Recently we have concentrated in indole-derivatives, derivatives that are exist in cruciferous vegetables, natural antioxidants, medicinal plants and medicinal mushrooms. The main goal of these studies is to elucidate such a novel and powerful natural compounds that can be used as an adjuvant nutritional therapy in preventing or a delaying the progression of cancer. The efficacy of these compounds will be tested in vitro using human cancer cells and in vivo using animal models. Moreover, the molecular mechanism of action of these factors will be studied in the cells using CHIP DNA analysis. These studies may lead to better understanding the biology of human cancer and may lead to the development of new strategies for prevention and treatment of human cancer.
3. The role of hormones in cancer development; studying the role of the indolic melatonin hormone in prevention of breast and prostate cancer. Over the last 120 years, increased exposure of humans to light at night imposed a long photoperiod of about 16-18 hours of light all year long, thus contributing to a of 'loss-of-seasonality'. Recent studies have linked disruption of normal circadian rhythms, via exposure to LAN, to the development of cancer. The indolic hormone melatonin (MLT) , considered as the universal regulator of biological rhythms, was found to have oncostatic and anti-proliferative effects in both in vitro and in vivo studies. Additionally, low levels of MLT may indirectly act to increase cancer risk by modulating the secretion of hormones implicated in carcinogenesis. In the current research we will determine the impact of 'loss-of-seasonality' due to long term exposure to light at night, experienced by the majority of people in the industrialized world, on the development of breast and prostate cancer in animal models. Moreover, the impact of MLT on the uptake of chemotherapeutic drugs (e.g. tamoxifen) administered during the day or night will be examined. Taken together, the results of our studies are expected to facilitate the formulation of guidelines regarding sensible use of illumination that will minimize the current risks associated with LAN without compromising our ability to work and live in a safe environment.
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