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Dr. Good’s laboratory focuses on the cellular and molecular mechanisms involved in the development of the gastrointestinal disease affecting premature infants called necrotizing enterocolitis (NEC). Utilizing a murine model of NEC, she studies the mechanism by which breast milk and amniotic fluid prevent the disease. She has shown that amniotic fluid inhibits Toll-like receptor (TLR4)-mediated pro-inflammatory signaling in the fetal and neonatal intestinal epithelium and prevents NEC via epidermal growth factor (EGF) receptor signaling (PNAS, 2012). Importantly, she has further demonstrated that one of the components in breast milk that is protective against NEC is EGF (Mucosal Immunology, 2015). She has also developed a large animal model of NEC with premature piglets and has begun testing therapeutics in this model (AJP-GI and Liver, 2014). Currently, she is focused on the intestinal mucosal host defense involved in NEC pathogenesis and the development of novel therapeutics for the disease.
Necrotizing Enterocolitis, Pediatric Research, Child Health
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