alexa Core Cross-linked Multifunctional Micelles For Targeted Breast Cancer Therapy
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

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9th World Congress on Materials Science and Engineering
June 12-14, 2017 Rome, Italy

Sevil Dincer Isoglu, Fatma Mohamed, Yasmine Doleyres and Peter X Ma
Abdullah Gül University, Turkey
University of Michigan, USA
Posters & Accepted Abstracts: J Material Sci Eng
DOI: 10.4172/2169-0022-C1-068
In this study, we investigated the efficiency of anticancer agent release to breast cancer cells by core cross-linked micelles prepared by controlled polymerization technique. First, block copolymers and micelles were synthesized by RAFT polymerization by using sulfobetaine together with temperature and pH-sensitive units and a cross-linker in the presence of ACVA as initiator. Structural and physicochemical characterizations were performed by NMR, FTIR and light scattering methods. Solubility and stability of micelles are attributed to the hydrophilic and zwitterionic nature of the sulfobetaine shell possessing a biocompatible nature. The inner part of micelles is temperature and pH-responsive, which can enhance the drug loading/release. Then, DOX, as a model drug, was loaded to micelles and release experiments were carried out in buffer conditions. For targeting breast cancer cells, a HER2-specific peptide was coupled to the micelles covalently. Micelle formulations were applied to HER2-expressing cancer cells (SKBR3), and specific delivery to the breast cancer cells compared to healthy ones was achieved.

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