alexa Core Cross-linked Multifunctional Micelles For Targeted Breast Cancer Therapy
ISSN: 2169-0022

Journal of Material Sciences & Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th World Congress on Materials Science and Engineering
June 12-14, 2017 Rome, Italy

Sevil Dincer Isoglu, Fatma Mohamed, Yasmine Doleyres and Peter X Ma
Abdullah Gül University, Turkey
University of Michigan, USA
Posters & Accepted Abstracts: J Material Sci Eng
DOI: 10.4172/2169-0022-C1-068
Abstract
In this study, we investigated the efficiency of anticancer agent release to breast cancer cells by core cross-linked micelles prepared by controlled polymerization technique. First, block copolymers and micelles were synthesized by RAFT polymerization by using sulfobetaine together with temperature and pH-sensitive units and a cross-linker in the presence of ACVA as initiator. Structural and physicochemical characterizations were performed by NMR, FTIR and light scattering methods. Solubility and stability of micelles are attributed to the hydrophilic and zwitterionic nature of the sulfobetaine shell possessing a biocompatible nature. The inner part of micelles is temperature and pH-responsive, which can enhance the drug loading/release. Then, DOX, as a model drug, was loaded to micelles and release experiments were carried out in buffer conditions. For targeting breast cancer cells, a HER2-specific peptide was coupled to the micelles covalently. Micelle formulations were applied to HER2-expressing cancer cells (SKBR3), and specific delivery to the breast cancer cells compared to healthy ones was achieved.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords