alexa Development And Validation Of An Analytical Methodology For The Simultaneous Quantitative Determination Of Synthetic Cathinones In Urine And Plasma Using GC-NCI-MS
ISSN: 2150-3494

Chemical Sciences Journal
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th European Chemistry Congress
May 11-13, 2017 Barcelona, Spain

Rashed Alremeithi, Mohammed A Meetani, Anas A Alaidaros, Adnan S Lanjawi and Khaled T Alsumaiti
United Arab Emirates University, UAE
Dubai police, UAE
Posters & Accepted Abstracts: Chem Sci J
DOI: 10.4172/2150-3494-C1-009
Abstract
Development and validation of sensitive and selective method for enantioseparation and quantitation of synthetic cathinones “bath salts” has been done by using GC-MS with chemical ionization source in negative mode (NCI). Indirect chiral separation of thirty six synthetic cathinone compounds have been achieved by using optically pure chiral derivatizing agent (CDA) called (S)- (–)-N- (trifluoroacetyl)pyrrolidine-2-carbonyl chloride (L-TPC) which converts cathinone enantiomers into diastereoisomers that can be separated on achiral columns. As a result of using Ultra inert 60 m column and performing slow heating rate (2 oC/min) on the GC oven, an observed enhancement in enantiomer peaks resolution have been achieved. An internal standard, (+)-cathinone, was used for quantitation of synthetic cathinone. Method validation in terms of linearities, limits of detection (LOD), limits of quantitation (LOQ), recoveries and reproducibilities have been obtained for fourteen selected compounds that ran simultaneously as a mixture after being spiked in urine and plasma. It was found that the LOD’s of the fourteen synthetic cathinones in urine was in the range of 0.02 -0.76 ppb and in plasma it was in the range of 0.02 - 0.34 ppb. While the LOQ’s of the mixture in urine was in the range of 0.07 - 2.31 ppb and in plasma it was in the range of 0.07 – 1.03 ppb. Unlike the Electron Impact ion source (EI), NCI showed higher sensitivity by three orders of magnitude by comparing with the previous results. The correlation coefficient (R2) values for the mixture components was found to be higher than 0.99.
Biography

Rashed Humaid Alremeithi has completed his PhD at the age of 28 years from United Arab Emirates University. He is working at Dubai Police forensic labortory. He has published 2 papers in reputed journals.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords