alexa Effect Of Drug-drug Interactions And Number Of Prescribed Medications On Intensive Care Unit Length Of Stay


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9th International Conference and Exhibition on Pharmacovigilance & Drug Safety
July 17-18, 2017 Munich, Germany

Arezoo Ashnagar, Mohammad Sistanizad, Donya Moslemzadeh and Sajjad Ashnagar
Shahid Beheshti University of Medical Sciences, Iran
Univeristy of Michigan, USA
Posters & Accepted Abstracts: J Pharmacovigil
DOI: 10.4172/2329-6887-C1-027
Abstract
An interaction occurs when the effects of one drug are changed by the presence of another drug, herbal medicine or food. Drugdrug interaction (DDI) is a type of adverse drug effect (ADE) that is important to be prevented due to its consequences. The aim of this study was to determine the frequency of DDIs during intensive care unit (ICU) stays and to determine whether the frequency of these adverse events was associated with ICU length of stay (LOS). This prospective study was conducted in the ICU of Imam Husain multispecialty teaching hospital. Patients aged >18, with more than a 48 h stay were included in the study. Verification of potential drug interactions was carried out using the online Lexi-Interact TM. The median LOS was determined by the Kaplan- Meier method and cox proportional hazards models were fitted to analyses the relationship between DDI and the LOS. A total of 250 patients (94 females and 156 males) were enrolled in the study and the prescription data of 3986 patients-day entered to the database. The mean age of patients was 52.42±22 years. The mean LOS was 15.9±16.3 days. A total of 50743 potential DDIs have been identified by Lexi-Interact TM, 7425 (14.66%) and 1043 (2.06%) of which were categorized as D and X, respectively. The Pearson’s correlation method showed that a prolonged ICU stay was positively associated with DDIs (p-value<0.001), also the Mann-Whitney test indicates a significant difference in the Los of patients with D and X interactions and patient without D and X interactions (p-value<0.001). This study showed that DDIs are associated with longer ICU stays. By decreasing the number of DDIs, especially type D and X, ICU stays and hospital costs will be decreased. Drug interactions leading to serious adverse effects are to be cautiously watched for when multiple drugs are used simultaneously.
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