alexa Half-sandwich Ruthenium-arene Complex Containing Heterocyclic Thiosemicarbazone: The X-ray Crystal Structures And DNA Interactions
ISSN: 2150-3494

Chemical Sciences Journal
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

4th European Chemistry Congress
May 11-13, 2017 Barcelona, Spain

Elif Subaşı, Pelin Kose Yaman, Birgul Kehlibar, Betul Sen, Cansu Sonay Karagoz and Hulya Ayar Kayali
Dokuz Eylul University, Turkey
Posters & Accepted Abstracts: Chem Sci J
DOI: 10.4172/2150-3494-C1-009
The organoruthenium complex [(η6-p-cym)Ru(η1-S-TSC)Cl2], (1) and (2-acetyl-5-methyl-thiophene thiosemicarbazone) TSC ligand were investigated in vitro for their properties as prospective anti-tumour agents. The complex and TSC have been characterized by elemental analysis, UV–Vis, FT-IR and 1H NMR spectroscopy. The crystal structures of TSC and (1) have been determined by X-ray crystallography and (1) represented as the first structurally characterized arene–ruthenium half-sandwich complex with a monodentate S coordinated TSC ligand. It is revealed that TSC, crystallized in the monoclinic space group P21/c and complex (1) shows a distorted octahedral geometry around the Ru centre. The mononuclear complex adopts a typical three legged piano-stool geometry with the metal centre coordinated by two chlorides and a TSC ligand. The cytotoxic activity of the complex against human ovarian (A2780, SKOV-3 and OVCAR-3) and colon (DLD, CCD-18Co, Caco-2) cell lines was investigated. The complex exhibit higher cytotoxicity in three cancer cell lines than in normal cell (CCD-18Co). The Caco-2 cell was especially susceptible to the complex, with an IC50 value (0.18 μM) lower than cisplatin (64.72 μM). The cytotoxic values of (1) treated A2780 cells (1.15 μM) was also lower than cisplatin treated (10.08 μM). The results showed that the complex exhibits the higher cytotoxicity against colon cell lines than ovarian cell lines. The cellular uptake and localization suggest that (1) can be successfully taken up by the all studied cells, and the complex can enter into the cytoplasm and accumulate in the cell nuclei. The cell cycle distribution shows that the complex inhibits the cell growth in the generally G0/G1 and/or G2/M phases arrest. These results show that the complex may be a potential anticancer drug.

Elif Subaşı has completed her MSc from University of Reading, England in 1996 and PhD from Ege University, Turkey in 2003 and postdoctoral studies from University College London, England. She works at Dokuz Eylul University from 2003 and she is a professor from 2012. She has published more than 25 papers in reputed journals.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version