alexa Research On Drug Release Performance Of Hydroxyapatite-gelatin Composites Produced In SBF Medium | 63908
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
Open Access

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2nd Annual Conference and Expo on BIOMATERIALS

Ebru Kahraman, Seckin Hacioglu, Tugba Basargan Ozsagiroglu, Nalan Erdol Aydin and Gulhayat Nasun Saygili
Istanbul Technical University, Turkey
Posters & Accepted Abstracts: J Biotechnol Biomater
DOI: 10.4172/2155-952X.C1.074
Abstract
Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is a bioseramic material found in bone and teeth composition which has apatite-like structure. In spite of its biocompatibility, bioactivity and nontoxicity, hydroxyapatite has been used for sentetic bone material production, bone and teeth implants and drug delivery applications. In recent years, studies aiming to use ceramic/polymer materials as drug carrier have gained importance. By adding biodegradable polymers with different degradation rate and mechanism to ceramic materials, variety of release profiles can be obtained. One of the polymers used in drug release systems is gelatin, which can be used alone or as a constituent of a composite. Not only being biocompatible, biodegradable and nontoxic, but also economic, made gelatin a preferable polymer in drug release studies. Given the side effects and high costs of systematical antibiotic treatments, controlled drug delivery studies performed with drug loaded composite materials have gained importance. In drug delivery studies with bioactive materials, it is observed that permeability and porosity of the material affect the release profile. As a result, having a highly similar structure with bone inorganic phase has caused hydroxyapatite to be preferred in several drug loading studies. In this study, hydroxyapatite-gelatin (HAp-GEL) composites are produced in the presence of SBF (Simulated Body Fluid) and spray dryer is used for obtaining drug loaded composites. Composites are produced by wet precipitation method implementing glutaraldehyde (GA) as a cross-linking agent. By running experiments with different amounts of gelatin and glutaraldehyde, their effects on encapsulation efficiency and drug release profiles are studied. Drug encapsulation experiments are performed with 5-FU as a selected drug. Drug release profiles are evaluated according to four different kinetic models including Zero Order, First Order, Higuchi and Korsmeyer-Peppas. The obtained composites are characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Thermogravimetric Analysis (TGA), and X-Ray Diffraction (XRD).
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